TY - JOUR
T1 - What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications
AU - Serafini, Marta
AU - Cargnin, Sarah
AU - Massarotti, Alberto
AU - Tron, Gian Cesare
AU - Pirali, Tracey
AU - Genazzani, Armando A.
N1 - Publisher Copyright:
© 2021 The Authors. Published by American Chemical Society.
PY - 2021/4/22
Y1 - 2021/4/22
N2 - The World Health Organization assigns international nonproprietary names (INN), also known as common names, to compounds upon request from drug developers. Structures of INNs are publicly available and represent a source, albeit underused, to understand trends in drug research and development. Here, we explain how a common drug name is composed and analyze chemical entities from 2000 to 2021. In the analysis, we describe some changes that intertwine chemical structure, newer therapeutic targets (e.g., kinases), including a significant increase in the use of fluorine and of heterocycles, and some other evolutionary modifications, such as the progressive increase in molecular weight. Alongside these, small signs of change can be spotted, such as the rise in spirocyclic scaffolds and small rings and the emergence of unconventional structural moieties that might forecast the future to come.
AB - The World Health Organization assigns international nonproprietary names (INN), also known as common names, to compounds upon request from drug developers. Structures of INNs are publicly available and represent a source, albeit underused, to understand trends in drug research and development. Here, we explain how a common drug name is composed and analyze chemical entities from 2000 to 2021. In the analysis, we describe some changes that intertwine chemical structure, newer therapeutic targets (e.g., kinases), including a significant increase in the use of fluorine and of heterocycles, and some other evolutionary modifications, such as the progressive increase in molecular weight. Alongside these, small signs of change can be spotted, such as the rise in spirocyclic scaffolds and small rings and the emergence of unconventional structural moieties that might forecast the future to come.
UR - https://www.scopus.com/pages/publications/85105108806
U2 - 10.1021/acs.jmedchem.1c00181
DO - 10.1021/acs.jmedchem.1c00181
M3 - Review article
SN - 0022-2623
VL - 64
SP - 4410
EP - 4429
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 8
ER -