Weak histamine H2-receptor blocking activity of ranitidine analogues containing conformationally restricted connecting chains

M. Orsetti

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The paper describes the activity of ranitidine analogues in which a rigid molecular conformation has been attained by the substitution of the flexible connecting chain with an o-phenylene unit. The results indicate that this structural manipulation causes a dramatic decrease of H2-blocking activity. It is concluded that the introduction of the o-phenylene imposes a geometrical constraint which results in a refolded molecular conformation.

Lingua originaleInglese
pagine (da-a)57-58
Numero di pagine2
RivistaMedical Science Research
Volume17
Numero di pubblicazione1
Stato di pubblicazionePubblicato - 1989
Pubblicato esternamente

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