Abstract
The paper describes the activity of ranitidine analogues in which a rigid molecular conformation has been attained by the substitution of the flexible connecting chain with an o-phenylene unit. The results indicate that this structural manipulation causes a dramatic decrease of H2-blocking activity. It is concluded that the introduction of the o-phenylene imposes a geometrical constraint which results in a refolded molecular conformation.
Lingua originale | Inglese |
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pagine (da-a) | 57-58 |
Numero di pagine | 2 |
Rivista | Medical Science Research |
Volume | 17 |
Numero di pubblicazione | 1 |
Stato di pubblicazione | Pubblicato - 1989 |
Pubblicato esternamente | Sì |