Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

Dario L. Longo; Rachele STEFANIA; Chiara Callari; Francesco De Rose; Riccardo Rolle; Laura Conti; Lorena Consolino; Francesca Arena; Silvio Aime

doi:10.1002/adhm.201600550

Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

Dario L. Longo, Rachele STEFANIA, Chiara Callari, Francesco De Rose, Riccardo Rolle, Laura Conti, Lorena Consolino, Francesca Arena, Silvio Aime

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.

Lingua originale	Inglese
Rivista	Advanced healthcare materials
Volume	6
Numero di pubblicazione	1
DOI	https://doi.org/10.1002/adhm.201600550
Stato di pubblicazione	Pubblicato - 2017

Keywords

dynamic contrast enhanced
melanin
nanoparticles
photoacoustic
tumors

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10.1002/adhm.201600550

https://hdl.handle.net/11579/184984

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title = "Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy",

abstract = "A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.",

keywords = "dynamic contrast enhanced, melanin, nanoparticles, photoacoustic, tumors, dynamic contrast enhanced, melanin, nanoparticles, photoacoustic, tumors",

author = "Longo, {Dario L.} and Rachele STEFANIA and Chiara Callari and {De Rose}, Francesco and Riccardo Rolle and Laura Conti and Lorena Consolino and Francesca Arena and Silvio Aime",

year = "2017",

doi = "10.1002/adhm.201600550",

language = "English",

volume = "6",

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T1 - Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

AU - Longo, Dario L.

AU - STEFANIA, Rachele

AU - Callari, Chiara

AU - De Rose, Francesco

AU - Rolle, Riccardo

AU - Conti, Laura

AU - Consolino, Lorena

AU - Arena, Francesca

AU - Aime, Silvio

PY - 2017

Y1 - 2017

N2 - A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.

AB - A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.

KW - dynamic contrast enhanced

KW - melanin

KW - nanoparticles

KW - photoacoustic

KW - tumors

KW - dynamic contrast enhanced

KW - melanin

KW - nanoparticles

KW - photoacoustic

KW - tumors

UR - https://iris.uniupo.it/handle/11579/184984

U2 - 10.1002/adhm.201600550

DO - 10.1002/adhm.201600550

M3 - Article

SN - 2192-2640

VL - 6

JO - Advanced healthcare materials

JF - Advanced healthcare materials

IS - 1

ER -

Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

Abstract

Keywords

OSS delle Nazioni Unite

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