TY - JOUR
T1 - Vitis vinifera L. Leaf Extract, a Microbiota Green Ally against
Infectious and Inflammatory Skin and Scalp Diseases:
An In-Depth Update
AU - Armari, M
AU - ZAVATTARO, Elisa
AU - CF, Trejo
AU - Galeazzi, A
AU - Grossetti, A
AU - Veronese, F
AU - SAVOIA, Paola
AU - AZZIMONTI, Barbara
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024
Y1 - 2024
N2 - The skin microbiota, with its millions of bacteria, fungi, and viruses, plays a key role in
balancing the health of the skin and scalp. Its continuous exposure to potentially harmful stressors
can lead to abnormalities such as local dysbiosis, altered barrier function, pathobiont overabundance,
and infections often sustained by multidrug-resistant bacteria. These factors contribute to skin
impairment, deregulation of immune response, and chronic inflammation, with local and systemic
consequences. In this scenario, according to the needs of the bio-circular-green economy model,
novel harmless strategies, both for regulating the diverse epidermal infectious and inflammatory
processes and for preserving or restoring the host skin eubiosis and barrier selectivity, are requested.
Vitis vinifera L. leaves and their derived extracts are rich in plant secondary metabolites, such as
polyphenols, with antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory properties
that can be further exploited through microbe-driven fermentation processes. On this premise, this
literature review aims to provide an informative summary of the most updated evidence on their
interactions with skin commensals and pathogens and on their ability to manage inflammatory
conditions and restore microbial biodiversity. The emerging research showcases the potential novel
beneficial ingredients for addressing various skincare concerns and advancing the cosmeceutics field
as well.
AB - The skin microbiota, with its millions of bacteria, fungi, and viruses, plays a key role in
balancing the health of the skin and scalp. Its continuous exposure to potentially harmful stressors
can lead to abnormalities such as local dysbiosis, altered barrier function, pathobiont overabundance,
and infections often sustained by multidrug-resistant bacteria. These factors contribute to skin
impairment, deregulation of immune response, and chronic inflammation, with local and systemic
consequences. In this scenario, according to the needs of the bio-circular-green economy model,
novel harmless strategies, both for regulating the diverse epidermal infectious and inflammatory
processes and for preserving or restoring the host skin eubiosis and barrier selectivity, are requested.
Vitis vinifera L. leaves and their derived extracts are rich in plant secondary metabolites, such as
polyphenols, with antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory properties
that can be further exploited through microbe-driven fermentation processes. On this premise, this
literature review aims to provide an informative summary of the most updated evidence on their
interactions with skin commensals and pathogens and on their ability to manage inflammatory
conditions and restore microbial biodiversity. The emerging research showcases the potential novel
beneficial ingredients for addressing various skincare concerns and advancing the cosmeceutics field
as well.
KW - Vitis vinifera L. leaf extract
KW - anti-inflammatory activity
KW - antimicrobial activity
KW - dysbiosis
KW - fermentation
KW - opportunistic pathogens
KW - postbiotics
KW - skin and scalp diseases
KW - skin microbiota
KW - Vitis vinifera L. leaf extract
KW - anti-inflammatory activity
KW - antimicrobial activity
KW - dysbiosis
KW - fermentation
KW - opportunistic pathogens
KW - postbiotics
KW - skin and scalp diseases
KW - skin microbiota
UR - https://iris.uniupo.it/handle/11579/186582
U2 - 10.3390/antibiotics13080697
DO - 10.3390/antibiotics13080697
M3 - Article
SN - 2079-6382
VL - 13
SP - 697
JO - Antibiotics
JF - Antibiotics
ER -