Vitiligo: Unmet Need, Management and Treatment Guidelines

Angelo Valerio Marzano, Silvia Alberti-Violetti, Carlo Alberto Maronese, Gianluca Avallone, CLAUDIO JOMMI

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Vitiligo is a chronic depigmenting disorder characterized by characteristic, non-scaly, chalky-white skin macules and patches, due to the loss of skin pigment. Its exact pathogenesis is still not fully un-derstood but it seems to be an autoimmune disease where the combination of genetic, environmental, and immune factors contributes to the destruction of melanocytes in the epidermis. Vitiligo is classified into different types based on its clinical characteristics and distribution patterns. The two main forms of vitiligo are non-segmental vitiligo (NSV) and segmental vitiligo (SV). NSV is the predominant form, characterized by symmetrical skin patches, that tend to evolve over time. In contrast, SV has unilateral or band-shaped lesions that progress rapidly but often stabilize early. Herein, current unmet needs in terms of psychosocial consequences and relative lack of valid therapeutic approaches are critically analyzed and put in perspective in the Italian prescribing scenario. Finally, available management guidelines are illustrated and briefly compared, to provide context for upcoming treatment options.
Lingua originaleInglese
RivistaDERMATOLOGY PRACTICAL & CONCEPTUAL
Volume13
Numero di pubblicazione4S2
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • vitiligo
  • unmet need
  • guidelines
  • clinical pathway

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