Vitamin E dietary supplementation inhibits transforming growth factor β1 gene expression in the rat liver

Maurizio Parola, Roberto Muraca, Irma Dianzani, Giuseppina Barrera, Gabriella Leonarduzzi, Paola Bendinelli, Roberta Piccoletti, Giuseppe Poli

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Overexpression of transforming growth factor β1 (TGFβ1) and increased transcription of pro-collagen type I, are known to represent major events implicated in the development of liver fibrosis under either experimental or clinical conditions. Here we report that long-term dietary vitamin E supplementation in animals undergoing an experimental model of liver fibrosis (induced by chronic treatment of rats with carbon tetrachloride) results in a net inhibition of both hepatic TGFβ1 and α2 (I) procollagen mRNA levels. Moreover, of striking interest is the observation that vitamin E supplementation per so down-modulates basal levels of TGFβ1 mRNA in the liver of untreated animals, suggesting that a dietary regimen rich in vitamin E may potentially interfere with both the initiation and progression of the fibrosclerotic processes.

Lingua originaleInglese
pagine (da-a)267-270
Numero di pagine4
RivistaFEBS Letters
Volume308
Numero di pubblicazione3
DOI
Stato di pubblicazionePubblicato - 24 ago 1992
Pubblicato esternamente

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