Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes

Silvia Savastio; Francesco Cadario; Sandra D'ALFONSO; Marta Stracuzzi; Erica Pozzi; Silvia Raviolo; Stefano Rizzollo; Luca Gigliotti; Elena Boggio; Giorgio Bellomo; Chiara Basagni; Gianni Bona; IVANA RABBONE; Umberto DIANZANI; Flavia PRODAM

doi:10.1210/clinem/dgaa588

Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes

Silvia Savastio, Francesco Cadario, Sandra D'ALFONSO, Marta Stracuzzi, Erica Pozzi, Silvia Raviolo, Stefano Rizzollo, Luca Gigliotti, Elena Boggio, Giorgio Bellomo, Chiara Basagni, Gianni Bona, IVANA RABBONE, Umberto DIANZANI, Flavia PRODAM

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Vitamin D plays an immunoregulatory activity. The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/ICOS + which seems to have a protective role in autoimmunity, in children with T1D and their healthy siblings (S). The secondary aim was to evaluate the impact of vitamin D supplementation on these subsets.

Lingua originale	Inglese
pagine (da-a)	588
Rivista	Journal of Clinical Endocrinology and Metabolism
Volume	105
Numero di pubblicazione	12
DOI	https://doi.org/10.1210/clinem/dgaa588
Stato di pubblicazione	Pubblicato - 2020

Keywords

Th 17
Treg
Type 1 diabetes
immunomodulation
vitamin D

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10.1210/clinem/dgaa588

https://hdl.handle.net/11579/115789

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Savastio, S., Cadario, F., D'ALFONSO, S., Stracuzzi, M., Pozzi, E., Raviolo, S., Rizzollo, S., Gigliotti, L., Boggio, E., Bellomo, G., Basagni, C., Bona, G., RABBONE, IVANA., DIANZANI, U., & PRODAM, F. (2020). Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes. Journal of Clinical Endocrinology and Metabolism, 105(12), 588. https://doi.org/10.1210/clinem/dgaa588

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title = "Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes",

abstract = "Vitamin D plays an immunoregulatory activity. The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/ICOS + which seems to have a protective role in autoimmunity, in children with T1D and their healthy siblings (S). The secondary aim was to evaluate the impact of vitamin D supplementation on these subsets.",

keywords = "Th 17, Treg, Type 1 diabetes, immunomodulation, vitamin D, Th 17, Treg, Type 1 diabetes, immunomodulation, vitamin D",

author = "Silvia Savastio and Francesco Cadario and Sandra D'ALFONSO and Marta Stracuzzi and Erica Pozzi and Silvia Raviolo and Stefano Rizzollo and Luca Gigliotti and Elena Boggio and Giorgio Bellomo and Chiara Basagni and Gianni Bona and IVANA RABBONE and Umberto DIANZANI and Flavia PRODAM",

year = "2020",

doi = "10.1210/clinem/dgaa588",

language = "English",

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Savastio, S, Cadario, F, D'ALFONSO, S, Stracuzzi, M, Pozzi, E, Raviolo, S, Rizzollo, S, Gigliotti, L, Boggio, E, Bellomo, G, Basagni, C, Bona, G, RABBONE, IVANA , DIANZANI, U & PRODAM, F 2020, 'Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes', Journal of Clinical Endocrinology and Metabolism, vol. 105, n. 12, pagg. 588. https://doi.org/10.1210/clinem/dgaa588

TY - JOUR

T1 - Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes

AU - Savastio, Silvia

AU - Cadario, Francesco

AU - D'ALFONSO, Sandra

AU - Stracuzzi, Marta

AU - Pozzi, Erica

AU - Raviolo, Silvia

AU - Rizzollo, Stefano

AU - Gigliotti, Luca

AU - Boggio, Elena

AU - Bellomo, Giorgio

AU - Basagni, Chiara

AU - Bona, Gianni

AU - RABBONE, IVANA

AU - DIANZANI, Umberto

AU - PRODAM, Flavia

PY - 2020

Y1 - 2020

N2 - Vitamin D plays an immunoregulatory activity. The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/ICOS + which seems to have a protective role in autoimmunity, in children with T1D and their healthy siblings (S). The secondary aim was to evaluate the impact of vitamin D supplementation on these subsets.

AB - Vitamin D plays an immunoregulatory activity. The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/ICOS + which seems to have a protective role in autoimmunity, in children with T1D and their healthy siblings (S). The secondary aim was to evaluate the impact of vitamin D supplementation on these subsets.

KW - Th 17

KW - Treg

KW - Type 1 diabetes

KW - immunomodulation

KW - vitamin D

KW - Th 17

KW - Treg

KW - Type 1 diabetes

KW - immunomodulation

KW - vitamin D

UR - https://iris.uniupo.it/handle/11579/115789

U2 - 10.1210/clinem/dgaa588

DO - 10.1210/clinem/dgaa588

M3 - Article

SN - 0021-972X

VL - 105

SP - 588

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 12

ER -

Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes

Abstract

Keywords

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