Verteporfin based silica nanoplatform for photodynamic therapy

E. Gianotti; B. Martins Estevão; I. Miletto; S. Tonello; F. Renò; L. Marchese

doi:10.1002/slct.201600004

Verteporfin based silica nanoplatform for photodynamic therapy

E. Gianotti, B. Martins Estevão, I. Miletto, S. Tonello, F. Renò, L. Marchese

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A highly efficient nanoplatform for photodynamic therapy was obtained by covalent conjugation of verteporfin with mesoporous silica nanoparticles. Verteporfin has an intense absorption band in the red region of the Vis spectrum ensuring a deeper tissue penetration; this feature makes verteporfin-based formulations particularly attractive for in vivo PDT applications. The verteporfin loading, dispersion and efficiency in the photoproduction and delivery of singlet oxygen (¹O₂) were carefully evaluated. In vitro tests have evidenced that the optimized nanoplatform is able to largely reduce HeLa cell proliferation after red-light irradiation.

Lingua originale	Inglese
pagine (da-a)	127-131
Numero di pagine	5
Rivista	ChemistrySelect
Volume	1
Numero di pubblicazione	2
DOI	https://doi.org/10.1002/slct.201600004
Stato di pubblicazione	Pubblicato - feb 2016

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10.1002/slct.201600004

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title = "Verteporfin based silica nanoplatform for photodynamic therapy",

abstract = "A highly efficient nanoplatform for photodynamic therapy was obtained by covalent conjugation of verteporfin with mesoporous silica nanoparticles. Verteporfin has an intense absorption band in the red region of the Vis spectrum ensuring a deeper tissue penetration; this feature makes verteporfin-based formulations particularly attractive for in vivo PDT applications. The verteporfin loading, dispersion and efficiency in the photoproduction and delivery of singlet oxygen (1O2) were carefully evaluated. In vitro tests have evidenced that the optimized nanoplatform is able to largely reduce HeLa cell proliferation after red-light irradiation.",

keywords = "Mesoporous silica nanoparticles, Photodynamic therapy, Verteporfin, cell proliferation reduction, singlet oxygen delivery",

author = "E. Gianotti and Estev{\~a}o, {B. Martins} and I. Miletto and S. Tonello and F. Ren{\`o} and L. Marchese",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2016",

month = feb,

doi = "10.1002/slct.201600004",

language = "English",

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AU - Gianotti, E.

AU - Estevão, B. Martins

AU - Miletto, I.

AU - Tonello, S.

AU - Renò, F.

AU - Marchese, L.

PY - 2016/2

Y1 - 2016/2

N2 - A highly efficient nanoplatform for photodynamic therapy was obtained by covalent conjugation of verteporfin with mesoporous silica nanoparticles. Verteporfin has an intense absorption band in the red region of the Vis spectrum ensuring a deeper tissue penetration; this feature makes verteporfin-based formulations particularly attractive for in vivo PDT applications. The verteporfin loading, dispersion and efficiency in the photoproduction and delivery of singlet oxygen (1O2) were carefully evaluated. In vitro tests have evidenced that the optimized nanoplatform is able to largely reduce HeLa cell proliferation after red-light irradiation.

AB - A highly efficient nanoplatform for photodynamic therapy was obtained by covalent conjugation of verteporfin with mesoporous silica nanoparticles. Verteporfin has an intense absorption band in the red region of the Vis spectrum ensuring a deeper tissue penetration; this feature makes verteporfin-based formulations particularly attractive for in vivo PDT applications. The verteporfin loading, dispersion and efficiency in the photoproduction and delivery of singlet oxygen (1O2) were carefully evaluated. In vitro tests have evidenced that the optimized nanoplatform is able to largely reduce HeLa cell proliferation after red-light irradiation.

KW - Mesoporous silica nanoparticles

KW - Photodynamic therapy

KW - Verteporfin

KW - cell proliferation reduction

KW - singlet oxygen delivery

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DO - 10.1002/slct.201600004

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JO - ChemistrySelect

JF - ChemistrySelect

IS - 2

ER -

Verteporfin based silica nanoplatform for photodynamic therapy

Abstract

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