Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC)

Daniele Campa; Rainer Claus; Lucie Dostal; Angelika Stein; Jenny Chang-Claude; Karina Meidtner; Heiner Boeing; Anja Olsen; Anne Tjønneland; Kim Overvad; Laudina Rodríguez; Catalina Bonet; Maria José Sánchez; Pilar Amiano; José María Huerta; Aurelio Barricarte; Kay Tee Khaw; Nicholas Wareham; Ruth C. Travis; Naomi E. Allen; Antonia Trichopoulou; Christina Bamia; Vassiliki Benetou; Domenico Palli; Claudia Agnoli; Salvatore Panico; Rosario Tumino; Carlotta Sacerdote; Henk Van Kranen; H. Bas Bueno-De-Mesquita; Petra H.M. Peeters; Carla H. Van Gils; Per Lenner; Malin Sund; Eiliv Lund; Inger Torhild Gram; Sabina Rinaldi; Veronique Chajes; Isabelle Romieu; Pierre Engel; Marie Christine Boutron-Ruault; Françoise Clavel-Chapelon; Afshan Siddiq; Elio Riboli; Federico Canzian; Rudolf Kaaks

doi:10.1007/s10549-010-1269-1

Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC)

Daniele Campa, Rainer Claus, Lucie Dostal, Angelika Stein, Jenny Chang-Claude, Karina Meidtner, Heiner Boeing, Anja Olsen, Anne Tjønneland, Kim Overvad, Laudina Rodríguez, Catalina Bonet, Maria José Sánchez, Pilar Amiano, José María Huerta, Aurelio Barricarte, Kay Tee Khaw, Nicholas Wareham, Ruth C. Travis, Naomi E. AllenAntonia Trichopoulou, Christina Bamia, Vassiliki Benetou, Domenico Palli, Claudia Agnoli, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Henk Van Kranen, H. Bas Bueno-De-Mesquita, Petra H.M. Peeters, Carla H. Van Gils, Per Lenner, Malin Sund, Eiliv Lund, Inger Torhild Gram, Sabina Rinaldi, Veronique Chajes, Isabelle Romieu, Pierre Engel, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Afshan Siddiq, Elio Riboli, Federico Canzian, Rudolf Kaaks

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

AMP-activated protein kinase (AMPK) is an energy sensing/signalling intracellular protein which is activated by an increase in the cellular AMP:ATP ratio after ATP depletion. Once activated, AMPK inhibits fatty acid synthesis and the Akt-mTOR pathway, and activates the p53-p21 axis. All these molecular mechanisms are thought to play a key role in breast carcinogenesis. We investigated the genetic variability of four genes encoding AMPK (PRKAA1, PRKAA2, PRKAB1 and PRKAB2). Using a tagging approach and selecting SNPs we covered all the common genetic variation of these genes. We tested association of tagging SNPs in our four candidate genes with breast cancer (BC) risk in a study of 1340 BC cases and 2536 controls nested into the European Prospective Investigation into Cancer and Nutrition (EPIC). Given the relevance of AMPK on fatty acid synthesis and the importance of body fatness as a BC risk factor, we tested association of SNPs and body-mass index as well. We observed no statistically significant association between the SNPs in the PRKAs genes and BC risk and BMI after correction for multiple testing.

Lingua originale	Inglese
pagine (da-a)	761-767
Numero di pagine	7
Rivista	Breast Cancer Research and Treatment
Volume	127
Numero di pubblicazione	3
DOI	https://doi.org/10.1007/s10549-010-1269-1
Stato di pubblicazione	Pubblicato - giu 2011
Pubblicato esternamente	Sì

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Campa, D., Claus, R., Dostal, L., Stein, A., Chang-Claude, J., Meidtner, K., Boeing, H., Olsen, A., Tjønneland, A., Overvad, K., Rodríguez, L., Bonet, C., Sánchez, M. J., Amiano, P., Huerta, J. M., Barricarte, A., Khaw, K. T., Wareham, N., Travis, R. C., ... Kaaks, R. (2011). Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC). Breast Cancer Research and Treatment, 127(3), 761-767. https://doi.org/10.1007/s10549-010-1269-1

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title = "Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC)",

abstract = "AMP-activated protein kinase (AMPK) is an energy sensing/signalling intracellular protein which is activated by an increase in the cellular AMP:ATP ratio after ATP depletion. Once activated, AMPK inhibits fatty acid synthesis and the Akt-mTOR pathway, and activates the p53-p21 axis. All these molecular mechanisms are thought to play a key role in breast carcinogenesis. We investigated the genetic variability of four genes encoding AMPK (PRKAA1, PRKAA2, PRKAB1 and PRKAB2). Using a tagging approach and selecting SNPs we covered all the common genetic variation of these genes. We tested association of tagging SNPs in our four candidate genes with breast cancer (BC) risk in a study of 1340 BC cases and 2536 controls nested into the European Prospective Investigation into Cancer and Nutrition (EPIC). Given the relevance of AMPK on fatty acid synthesis and the importance of body fatness as a BC risk factor, we tested association of SNPs and body-mass index as well. We observed no statistically significant association between the SNPs in the PRKAs genes and BC risk and BMI after correction for multiple testing.",

keywords = "AMP-activated protein kinase, Body-mass index, Breast cancer, Cancer susceptibility",

author = "Daniele Campa and Rainer Claus and Lucie Dostal and Angelika Stein and Jenny Chang-Claude and Karina Meidtner and Heiner Boeing and Anja Olsen and Anne Tj{\o}nneland and Kim Overvad and Laudina Rodr{\'i}guez and Catalina Bonet and S{\'a}nchez, {Maria Jos{\'e}} and Pilar Amiano and Huerta, {Jos{\'e} Mar{\'i}a} and Aurelio Barricarte and Khaw, {Kay Tee} and Nicholas Wareham and Travis, {Ruth C.} and Allen, {Naomi E.} and Antonia Trichopoulou and Christina Bamia and Vassiliki Benetou and Domenico Palli and Claudia Agnoli and Salvatore Panico and Rosario Tumino and Carlotta Sacerdote and {Van Kranen}, Henk and {Bas Bueno-De-Mesquita}, H. and Peeters, {Petra H.M.} and {Van Gils}, {Carla H.} and Per Lenner and Malin Sund and Eiliv Lund and Gram, {Inger Torhild} and Sabina Rinaldi and Veronique Chajes and Isabelle Romieu and Pierre Engel and Boutron-Ruault, {Marie Christine} and Fran{\c c}oise Clavel-Chapelon and Afshan Siddiq and Elio Riboli and Federico Canzian and Rudolf Kaaks",

year = "2011",

month = jun,

doi = "10.1007/s10549-010-1269-1",

language = "English",

volume = "127",

pages = "761--767",

journal = "Breast Cancer Research and Treatment",

issn = "0167-6806",

publisher = "Springer",

number = "3",

}

Campa, D, Claus, R, Dostal, L, Stein, A, Chang-Claude, J, Meidtner, K, Boeing, H, Olsen, A, Tjønneland, A, Overvad, K, Rodríguez, L, Bonet, C, Sánchez, MJ, Amiano, P, Huerta, JM, Barricarte, A, Khaw, KT, Wareham, N, Travis, RC, Allen, NE, Trichopoulou, A, Bamia, C, Benetou, V, Palli, D, Agnoli, C, Panico, S, Tumino, R, Sacerdote, C, Van Kranen, H, Bas Bueno-De-Mesquita, H, Peeters, PHM, Van Gils, CH, Lenner, P, Sund, M, Lund, E, Gram, IT, Rinaldi, S, Chajes, V, Romieu, I, Engel, P, Boutron-Ruault, MC, Clavel-Chapelon, F, Siddiq, A, Riboli, E, Canzian, F & Kaaks, R 2011, 'Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC)', Breast Cancer Research and Treatment, vol. 127, n. 3, pagg. 761-767. https://doi.org/10.1007/s10549-010-1269-1

TY - JOUR

T1 - Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC)

AU - Campa, Daniele

AU - Claus, Rainer

AU - Dostal, Lucie

AU - Stein, Angelika

AU - Chang-Claude, Jenny

AU - Meidtner, Karina

AU - Boeing, Heiner

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Rodríguez, Laudina

AU - Bonet, Catalina

AU - Sánchez, Maria José

AU - Amiano, Pilar

AU - Huerta, José María

AU - Barricarte, Aurelio

AU - Khaw, Kay Tee

AU - Wareham, Nicholas

AU - Travis, Ruth C.

AU - Allen, Naomi E.

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Benetou, Vassiliki

AU - Palli, Domenico

AU - Agnoli, Claudia

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Van Kranen, Henk

AU - Bas Bueno-De-Mesquita, H.

AU - Peeters, Petra H.M.

AU - Van Gils, Carla H.

AU - Lenner, Per

AU - Sund, Malin

AU - Lund, Eiliv

AU - Gram, Inger Torhild

AU - Rinaldi, Sabina

AU - Chajes, Veronique

AU - Romieu, Isabelle

AU - Engel, Pierre

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Françoise

AU - Siddiq, Afshan

AU - Riboli, Elio

AU - Canzian, Federico

AU - Kaaks, Rudolf

PY - 2011/6

Y1 - 2011/6

N2 - AMP-activated protein kinase (AMPK) is an energy sensing/signalling intracellular protein which is activated by an increase in the cellular AMP:ATP ratio after ATP depletion. Once activated, AMPK inhibits fatty acid synthesis and the Akt-mTOR pathway, and activates the p53-p21 axis. All these molecular mechanisms are thought to play a key role in breast carcinogenesis. We investigated the genetic variability of four genes encoding AMPK (PRKAA1, PRKAA2, PRKAB1 and PRKAB2). Using a tagging approach and selecting SNPs we covered all the common genetic variation of these genes. We tested association of tagging SNPs in our four candidate genes with breast cancer (BC) risk in a study of 1340 BC cases and 2536 controls nested into the European Prospective Investigation into Cancer and Nutrition (EPIC). Given the relevance of AMPK on fatty acid synthesis and the importance of body fatness as a BC risk factor, we tested association of SNPs and body-mass index as well. We observed no statistically significant association between the SNPs in the PRKAs genes and BC risk and BMI after correction for multiple testing.

AB - AMP-activated protein kinase (AMPK) is an energy sensing/signalling intracellular protein which is activated by an increase in the cellular AMP:ATP ratio after ATP depletion. Once activated, AMPK inhibits fatty acid synthesis and the Akt-mTOR pathway, and activates the p53-p21 axis. All these molecular mechanisms are thought to play a key role in breast carcinogenesis. We investigated the genetic variability of four genes encoding AMPK (PRKAA1, PRKAA2, PRKAB1 and PRKAB2). Using a tagging approach and selecting SNPs we covered all the common genetic variation of these genes. We tested association of tagging SNPs in our four candidate genes with breast cancer (BC) risk in a study of 1340 BC cases and 2536 controls nested into the European Prospective Investigation into Cancer and Nutrition (EPIC). Given the relevance of AMPK on fatty acid synthesis and the importance of body fatness as a BC risk factor, we tested association of SNPs and body-mass index as well. We observed no statistically significant association between the SNPs in the PRKAs genes and BC risk and BMI after correction for multiple testing.

KW - AMP-activated protein kinase

KW - Body-mass index

KW - Breast cancer

KW - Cancer susceptibility

UR - http://www.scopus.com/inward/record.url?scp=79958264925&partnerID=8YFLogxK

U2 - 10.1007/s10549-010-1269-1

DO - 10.1007/s10549-010-1269-1

M3 - Article

SN - 0167-6806

VL - 127

SP - 761

EP - 767

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 3

ER -

Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC)

Abstract

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