Value of serum C-reactive protein measurement in the detection of hepatocellular carcinoma superimposed on liver cirrhosis

Carlo Fabris, Mario Pirisi, Giorgio Soardo, Edmondo Falleti, Francesca Pezzetta, Daniela Vitulli, Pierluigi Toniutto, Nadia Bortolotti, Fabio Gonano, Ettore Bartoli

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

We investigated whether, in Italian patients, C-reactive protein (CRP) determination could be considered a useful adjunct, complementary to α1-fetoprotein, in the detection of liver cancer. CRP was determined by particle-enhanced nephelometry in 171 subjects (102 male, 69 female). Fifty-five patients had mild chronic liver disease (CLD), 45 cirrhosis (CIR), 38 hepatocellular carcinoma (HCC); 33 subjects were healthy controls. Patients with HCC and CIR had higher CRP levels (P<0.05) than those found in patients with CLD and controls. CRP higher than 5 mg/l was found in 30/38 (78.9%) patients with HCC, 28/45 (62.2%) patients with CIR, 16/55 (29.1%) patients with CLD (χ2 56.0, P<0.0001). Sensitivity, specificity and diagnostic accuracy of CRP in diagnosing HCC with respect to CLD+CIR were: 78.9%, 56.0% and 34.9%. However, when considered only in the subgroup of patients with α1-fetoprotein below or equalling 30 ng/ml, they were 50.0%, 54.3% and 4.3% respectively. In conclusion, CRP concentration is frequently elevated in patients with HCC, however, it does not seem to improve the ability of α1-fetoprotein to discriminate HCC from CIR.

Lingua originaleInglese
pagine (da-a)229-232
Numero di pagine4
RivistaJournal of Cancer Research and Clinical Oncology
Volume120
Numero di pubblicazione4
DOI
Stato di pubblicazionePubblicato - feb 1994
Pubblicato esternamente

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