Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)-acetamidato complex

Giorgio Pelosi; Mauro Ravera; Elisabetta Gabano; Federico Fregonese; Domenico Osella

doi:10.1039/c5cc02477c

Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)-acetamidato complex

Giorgio Pelosi, Mauro Ravera, Elisabetta Gabano, Federico Fregonese, Domenico Osella

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We describe herein a novel Pt(iv)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(iv) complex containing a N-donor ligand coordinated during the Pt(ii) → Pt(iv) oxidation step. Remarkably, the Pt(iv)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(iv) antitumor prodrugs.

Lingua originale	Inglese
pagine (da-a)	8051-8053
Numero di pagine	3
Rivista	Chemical Communications
Volume	51
Numero di pubblicazione	38
DOI	https://doi.org/10.1039/c5cc02477c
Stato di pubblicazione	Pubblicato - 11 mag 2015

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10.1039/c5cc02477c

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title = "Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)-acetamidato complex",

abstract = "We describe herein a novel Pt(iv)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(iv) complex containing a N-donor ligand coordinated during the Pt(ii) → Pt(iv) oxidation step. Remarkably, the Pt(iv)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(iv) antitumor prodrugs.",

author = "Giorgio Pelosi and Mauro Ravera and Elisabetta Gabano and Federico Fregonese and Domenico Osella",

note = "Publisher Copyright: {\textcopyright} 2015 The Royal Society of Chemistry.",

year = "2015",

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doi = "10.1039/c5cc02477c",

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AU - Pelosi, Giorgio

AU - Ravera, Mauro

AU - Gabano, Elisabetta

AU - Fregonese, Federico

AU - Osella, Domenico

PY - 2015/5/11

Y1 - 2015/5/11

N2 - We describe herein a novel Pt(iv)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(iv) complex containing a N-donor ligand coordinated during the Pt(ii) → Pt(iv) oxidation step. Remarkably, the Pt(iv)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(iv) antitumor prodrugs.

AB - We describe herein a novel Pt(iv)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(iv) complex containing a N-donor ligand coordinated during the Pt(ii) → Pt(iv) oxidation step. Remarkably, the Pt(iv)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(iv) antitumor prodrugs.

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JF - Chemical Communications

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ER -

Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)-acetamidato complex

Abstract

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