Unnatural Natural Products from the Transannular Cyclization of Lathyrane Diterpenes

Giovanni Appendino; Gian Cesare Tron; Tomas Jarevång; Olov Sterner

doi:10.1021/ol0155541

Unnatural Natural Products from the Transannular Cyclization of Lathyrane Diterpenes

Giovanni Appendino, Gian Cesare Tron, Tomas Jarevång, Olov Sterner

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

(matrix presented) The potential of macrocyclic diterpenoids to afford natural product-like polycyclic compounds was demonstrated by the conversion of two lathyrane Euphorbia factors into a series of densely functionalized diterpenoids of unnatural skeletal type. Apparently, Nature is far from having fully exploited the built-in reactivity of these compounds to generate chemical diversity.

Lingua originale	Inglese
pagine (da-a)	1609-1612
Numero di pagine	4
Rivista	Organic Letters
Volume	3
Numero di pubblicazione	11
DOI	https://doi.org/10.1021/ol0155541
Stato di pubblicazione	Pubblicato - 31 mag 2001

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10.1021/ol0155541

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title = "Unnatural Natural Products from the Transannular Cyclization of Lathyrane Diterpenes",

abstract = "(matrix presented) The potential of macrocyclic diterpenoids to afford natural product-like polycyclic compounds was demonstrated by the conversion of two lathyrane Euphorbia factors into a series of densely functionalized diterpenoids of unnatural skeletal type. Apparently, Nature is far from having fully exploited the built-in reactivity of these compounds to generate chemical diversity.",

author = "Giovanni Appendino and Tron, \{Gian Cesare\} and Tomas Jarev{\aa}ng and Olov Sterner",

year = "2001",

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AU - Jarevång, Tomas

AU - Sterner, Olov

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AB - (matrix presented) The potential of macrocyclic diterpenoids to afford natural product-like polycyclic compounds was demonstrated by the conversion of two lathyrane Euphorbia factors into a series of densely functionalized diterpenoids of unnatural skeletal type. Apparently, Nature is far from having fully exploited the built-in reactivity of these compounds to generate chemical diversity.

UR - https://www.scopus.com/pages/publications/0035979044

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JO - Organic Letters

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Unnatural Natural Products from the Transannular Cyclization of Lathyrane Diterpenes

Abstract

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