Tumour-associated macrophages as a prototypic type II polarised phagocyte population: Role in tumour progression

Alberto Mantovani; Paola Allavena; Antonio Sica

doi:10.1016/j.ejca.2004.03.016

Tumour-associated macrophages as a prototypic type II polarised phagocyte population: Role in tumour progression

Alberto Mantovani, Paola Allavena, Antonio Sica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Macrophages are versatile, plastic cells which respond to micro-environmental signals with distinct functional programmes. In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression.

Lingua originale	Inglese
pagine (da-a)	1660-1667
Numero di pagine	8
Rivista	European Journal of Cancer
Volume	40
Numero di pubblicazione	11
DOI	https://doi.org/10.1016/j.ejca.2004.03.016
Stato di pubblicazione	Pubblicato - lug 2004
Pubblicato esternamente	Sì

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10.1016/j.ejca.2004.03.016

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title = "Tumour-associated macrophages as a prototypic type II polarised phagocyte population: Role in tumour progression",

abstract = "Macrophages are versatile, plastic cells which respond to micro-environmental signals with distinct functional programmes. In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression.",

keywords = "Polarised phagocyte populations, Tumour progression, Tumour-associated macrophages",

author = "Alberto Mantovani and Paola Allavena and Antonio Sica",

year = "2004",

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AU - Allavena, Paola

AU - Sica, Antonio

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AB - Macrophages are versatile, plastic cells which respond to micro-environmental signals with distinct functional programmes. In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression.

KW - Polarised phagocyte populations

KW - Tumour progression

KW - Tumour-associated macrophages

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JO - European Journal of Cancer

JF - European Journal of Cancer

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Tumour-associated macrophages as a prototypic type II polarised phagocyte population: Role in tumour progression

Abstract

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