Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer

Haonan Lu; Hantao Lou; Georg Wengert; Reema Paudel; Naina Patel; Saral Desai; Bill Crum; Kristofer Linton-Reid; Mitchell Chen; Dongyang Li; Jacey Ip; Francesco Mauri; David J. Pinato; Andrea Rockall; Susan J. Copley; Sadaf Ghaem-Maghami; Eric O. Aboagye

doi:10.1016/j.xcrm.2023.101092

Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer

Haonan Lu, Hantao Lou, Georg Wengert, Reema Paudel, Naina Patel, Saral Desai, Bill Crum, Kristofer Linton-Reid, Mitchell Chen, Dongyang Li, Jacey Ip, Francesco Mauri, David J. Pinato, Andrea Rockall, Susan J. Copley, Sadaf Ghaem-Maghami, Eric O. Aboagye

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Tertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm that TLS-high HGSOC patients show significantly better progression-free survival (PFS). We show that the presence of TLS in HGSOC tumors is associated with B cell maturation and cytotoxic tumor-specific T cell activation and proliferation. In addition, the copy-number loss of IL15 and CXCL10 may limit TLS formation in HGSOC; a list of genes that may dysregulate TLS function is also proposed. Last, a radiomics-based signature is developed to predict the presence of TLS, which independently predicts PFS in both HGSOC patients and immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients. Overall, we reveal that TLS coordinates intratumoral B cell and T cell response to HGSOC tumor, while the cancer genome evolves to counteract TLS formation and function.

Lingua originale	Inglese
Numero di articolo	101092
Rivista	Cell Reports Medicine
Volume	4
Numero di pubblicazione	7
DOI	https://doi.org/10.1016/j.xcrm.2023.101092
Stato di pubblicazione	Pubblicato - 18 lug 2023

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10.1016/j.xcrm.2023.101092

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Lu, H., Lou, H., Wengert, G., Paudel, R., Patel, N., Desai, S., Crum, B., Linton-Reid, K., Chen, M., Li, D., Ip, J., Mauri, F., Pinato, D. J., Rockall, A., Copley, S. J., Ghaem-Maghami, S., & Aboagye, E. O. (2023). Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer. Cell Reports Medicine, 4(7), Articolo 101092. https://doi.org/10.1016/j.xcrm.2023.101092

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title = "Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer",

abstract = "Tertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm that TLS-high HGSOC patients show significantly better progression-free survival (PFS). We show that the presence of TLS in HGSOC tumors is associated with B cell maturation and cytotoxic tumor-specific T cell activation and proliferation. In addition, the copy-number loss of IL15 and CXCL10 may limit TLS formation in HGSOC; a list of genes that may dysregulate TLS function is also proposed. Last, a radiomics-based signature is developed to predict the presence of TLS, which independently predicts PFS in both HGSOC patients and immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients. Overall, we reveal that TLS coordinates intratumoral B cell and T cell response to HGSOC tumor, while the cancer genome evolves to counteract TLS formation and function.",

keywords = "CNA, ovarian cancer, radiomics, tertiary lymphoid structures",

author = "Haonan Lu and Hantao Lou and Georg Wengert and Reema Paudel and Naina Patel and Saral Desai and Bill Crum and Kristofer Linton-Reid and Mitchell Chen and Dongyang Li and Jacey Ip and Francesco Mauri and Pinato, \{David J.\} and Andrea Rockall and Copley, \{Susan J.\} and Sadaf Ghaem-Maghami and Aboagye, \{Eric O.\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

month = jul,

day = "18",

doi = "10.1016/j.xcrm.2023.101092",

language = "English",

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Lu, H, Lou, H, Wengert, G, Paudel, R, Patel, N, Desai, S, Crum, B, Linton-Reid, K, Chen, M, Li, D, Ip, J, Mauri, F, Pinato, DJ, Rockall, A, Copley, SJ, Ghaem-Maghami, S & Aboagye, EO 2023, 'Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer', Cell Reports Medicine, vol. 4, n. 7, 101092. https://doi.org/10.1016/j.xcrm.2023.101092

TY - JOUR

T1 - Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer

AU - Lu, Haonan

AU - Lou, Hantao

AU - Wengert, Georg

AU - Paudel, Reema

AU - Patel, Naina

AU - Desai, Saral

AU - Crum, Bill

AU - Linton-Reid, Kristofer

AU - Chen, Mitchell

AU - Li, Dongyang

AU - Ip, Jacey

AU - Mauri, Francesco

AU - Pinato, David J.

AU - Rockall, Andrea

AU - Copley, Susan J.

AU - Ghaem-Maghami, Sadaf

AU - Aboagye, Eric O.

PY - 2023/7/18

Y1 - 2023/7/18

N2 - Tertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm that TLS-high HGSOC patients show significantly better progression-free survival (PFS). We show that the presence of TLS in HGSOC tumors is associated with B cell maturation and cytotoxic tumor-specific T cell activation and proliferation. In addition, the copy-number loss of IL15 and CXCL10 may limit TLS formation in HGSOC; a list of genes that may dysregulate TLS function is also proposed. Last, a radiomics-based signature is developed to predict the presence of TLS, which independently predicts PFS in both HGSOC patients and immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients. Overall, we reveal that TLS coordinates intratumoral B cell and T cell response to HGSOC tumor, while the cancer genome evolves to counteract TLS formation and function.

AB - Tertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm that TLS-high HGSOC patients show significantly better progression-free survival (PFS). We show that the presence of TLS in HGSOC tumors is associated with B cell maturation and cytotoxic tumor-specific T cell activation and proliferation. In addition, the copy-number loss of IL15 and CXCL10 may limit TLS formation in HGSOC; a list of genes that may dysregulate TLS function is also proposed. Last, a radiomics-based signature is developed to predict the presence of TLS, which independently predicts PFS in both HGSOC patients and immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients. Overall, we reveal that TLS coordinates intratumoral B cell and T cell response to HGSOC tumor, while the cancer genome evolves to counteract TLS formation and function.

KW - CNA

KW - ovarian cancer

KW - radiomics

KW - tertiary lymphoid structures

UR - https://www.scopus.com/pages/publications/85165520991

U2 - 10.1016/j.xcrm.2023.101092

DO - 10.1016/j.xcrm.2023.101092

M3 - Article

SN - 2666-3791

VL - 4

JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 7

M1 - 101092

ER -

Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer

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