Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA

David T. Puerta, Mauro Botta, Christoph J. Jocher, Eric J. Werner, Stefano Avedano, Kenneth N. Raymond, Seth M. Cohen

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]2- at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents.

Lingua originaleInglese
pagine (da-a)2222-2223
Numero di pagine2
RivistaJournal of the American Chemical Society
Volume128
Numero di pubblicazione7
DOI
Stato di pubblicazionePubblicato - 22 feb 2006

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