Abstract
Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]2- at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents.
Lingua originale | Inglese |
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pagine (da-a) | 2222-2223 |
Numero di pagine | 2 |
Rivista | Journal of the American Chemical Society |
Volume | 128 |
Numero di pubblicazione | 7 |
DOI | |
Stato di pubblicazione | Pubblicato - 22 feb 2006 |