Abstract
Introduction of small unsaturated alkylamino groups at the 4-position of the A-ring of the tricyclic framework (triazafluorenone) afforded extremely potent and selective mGluR1 antagonists with desirable properties. Compounds 11q and 11s are active in the SNL pain model with ED50s 3.3 and 6.4 mg/kg respectively. Metabolic outcome of propargyl amino moiety was studied.
Lingua originale | Inglese |
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pagine (da-a) | 3199-3203 |
Numero di pagine | 5 |
Rivista | Bioorganic and Medicinal Chemistry Letters |
Volume | 19 |
Numero di pubblicazione | 12 |
DOI | |
Stato di pubblicazione | Pubblicato - 15 giu 2009 |
Pubblicato esternamente | Sì |