TY - JOUR
T1 - Tricyclic drugs as microemulsion cosurfactants
AU - Pattarino, F.
AU - Cavalli, R.
AU - Gasco, M. R.
PY - 1996
Y1 - 1996
N2 - To assess the possibility of using drugs as cosurfactants in microemulsions, o/w systems were prepared, containing 1-decanol/1-dodecanol as oil, water, Cremophor EL or Epikuron 200 (soybean lecithin) as surfactant and one of eight phenothiazines (chlorpromazine, aminopromazine, promazine, promethazine, triflupromazine, trifluperazine, levomepromazine, dietazine) and six other tricyclic amines (amitriptyline, clomipramine, desipramine, dimethacrine, imipramine, nortriptyline) as cosurfactant. Phase diagrams of quaternary systems with Cremophor EL and the selected drugs were explored and the areas of existence of stable microemulsions identified. Not all the drugs were able to give clear isotropic systems at room temperature; trifluperazine failed to form microemulsious. For systems containing Epikuron 200, the minimum amount of drug required to form a microemulsion was determined. Transparent systems were obtained with all examined drugs; the percentages of cosurfactant were relatively low and quite similar for all drugs.
AB - To assess the possibility of using drugs as cosurfactants in microemulsions, o/w systems were prepared, containing 1-decanol/1-dodecanol as oil, water, Cremophor EL or Epikuron 200 (soybean lecithin) as surfactant and one of eight phenothiazines (chlorpromazine, aminopromazine, promazine, promethazine, triflupromazine, trifluperazine, levomepromazine, dietazine) and six other tricyclic amines (amitriptyline, clomipramine, desipramine, dimethacrine, imipramine, nortriptyline) as cosurfactant. Phase diagrams of quaternary systems with Cremophor EL and the selected drugs were explored and the areas of existence of stable microemulsions identified. Not all the drugs were able to give clear isotropic systems at room temperature; trifluperazine failed to form microemulsious. For systems containing Epikuron 200, the minimum amount of drug required to form a microemulsion was determined. Transparent systems were obtained with all examined drugs; the percentages of cosurfactant were relatively low and quite similar for all drugs.
KW - amphiphilic drugs
KW - cosurfactants
KW - formulation
KW - microemulsions
KW - tricyclic drugs
UR - http://www.scopus.com/inward/record.url?scp=0030513717&partnerID=8YFLogxK
M3 - Article
SN - 1121-2098
VL - 7
SP - 93
EP - 100
JO - Acta Technologiae et Legis Medicamenti
JF - Acta Technologiae et Legis Medicamenti
IS - 2
ER -