@article{6c53ff6cf73549dfa421dca0df6cfff6,
title = "Trends in survival after childhood cancer in Europe, 1978-1997: Report from the Automated Childhood Cancer Information System project (ACCIS)",
abstract = "This study, originating in the Automated Childhood Cancer Information System (ACCIS), evaluated the time trend in survival after childhood cancer in Europe. The study included more than 72,000 childhood cancer cases aged 0-14 years diagnosed in 1978-1997 and followed-up in 30 population-based cancer registries with a long history of registration and follow-up, in 15 European countries. Survival was analysed using an actuarial life-table method. Five-year cumulative survival probability increased significantly over the study period for all tumour types combined, from 54% for cases diagnosed in the period 1978-1982 to 75% in 1993-1997. Significant improvement was also observed in 10-year survival. Comparing the results for the period 1993-1997 with those for 1978-1982, the largest relative increase in survival was seen for hepatic tumours (32%) and the largest reduction in mortality for non-Hodgkin's lymphomas (60%). Least progress was seen for central nervous system (CNS) tumours. The improvement was statistically significant in all European regions and was most rapid in the East. The ranking among the European regions did not change over the study period, with highest survival in the North and the West and lowest in the East. Extended data collection is necessary to evaluate future time trends and changes in differences between European regions.",
keywords = "Cancer, Childhood, Epidemiology, Europe, Infants, Leukaemia, Registry, Survival",
author = "Corrado Magnani and Guido Pastore and Coebergh, {Jan Willem} and Silvia Viscomi and Claudia Spix and Eva Steliarova-Foucher and H. Storm and N. Christensen and T. Aareleid and T. Hakulinen and R. Sankila and E. Pukkala and B. Lacour and E. Desandes and Bernard, {J. L.} and P. Pillon and Gentet, {J. C.} and L. Remontet and A. Danzon and M. Mercier and M. Velten and N. Raverdy and P. Kaatsch and B. Eisinger and R. Stabenow and D. Schuler and Z. Jakab and G. Borgulya and L. Tryggvadottir and Jonasson, {J. G.} and K. Bjarnadottir and E. Conti and V. Ramazzotti and Cercato, {M. C.} and P. Crosignani and G. Tagliabue and A. Tittarelli and {De Lisi}, V. and P. Sgargi and R. Tumino and {de Ridder-Sluiter}, H. and F. Langmark and A. Johansen and A. Andersen and I. Plesko and {Primic Z? akelj}, M. and V. Pompe-Kirn and {Ramon Quiros Garcia}, J. and {Can ada Mart{\'i}nez}, A. and E. Ardanaz and {Borr{\`a} s}, J. and J. Galceran and {de la B{\'a}rcena Guallar}, J. and {Martos Jim{\'e}nez}, {M. C.} and G. Jundt and C. Bouchardy and M. Usel and T. Fisch and S. Ess and Stiller, {C. A.} and Murphy, {M. F.G.} and Draper, {G. J.} and D. Brewster and L. Bhatti and A. McDonald",
note = "Funding Information: The ACCIS project was funded by the European Commission from {\textquoteleft}Europe Against Cancer{\textquoteright} action programme (1996–2002) (contracts SI2.126875, SI2.321970 and SPC.2002303), jointly with International Agency for Research on Cancer. Data analyses were partly financed by the French Ligue National Contre le Cancer, Comit{\'e} du Rh{\^o}ne. The activity of S.V. was supported by CPO-Piemonte (intramural research activity financed by the Piemonte Region). The authors thank Mr Nicolas Mitton for his input to the set-up, management and exploration of the ACCIS database, the members of ACCIS Scientific Committee for steering the study and the Guest Editors, in particular C.A. Stiller, for comments on earlier drafts. The following collaborators from the cancer registries contributed actively to this study: H. Storm, N. Christensen (Denmark); T. Aareleid (Estonia); T. Hakulinen, R. Sankila, E. Pukkala (Finland); B. Lacour, E. Desandes (Lorraine, France), J.L. Bernard, P. Pillon, J.C. Gentet (PACA and Corsica, France), L. Remontet (Francim, France), A. Danzon, M. Mercier (Doubs, France), M. Velten (Bas-Rhin, France), N. Raverdy (Somme, France); P. Kaatsch, B. Eisinger, R. Stabenow (Germany); D. Schuler, Z. Jakab, G. Borgulya (Hungary); L. Tryggvadottir, J.G. Jonasson, K. Bjarnadottir (Iceland); C. Magnani, G. Pastore (Piedmont, Italy), E. Conti, V. Ramazzotti, M.C. Cercato (Latina Province, Italy), P. Crosignani, G. Tagliabue, A. Tittarelli (Lombardy, Italy), V. De Lisi, P. Sgargi (Parma, Italy), R. Tumino (Ragusa, Italy); J.W. Coebergh, H. de Ridder-Sluiter (Netherlands); F. Langmark, A. Johansen, A. Andersen (Norway); I. Plesko (Slovakia); M. Primic {\v Z}akelj, V. Pompe-Kirn (Slovenia); J. Ramon Quiros Garcia, A. Ca{\~n}ada Martı´nez (Asturias, Spain), E. Ardanaz (Navarra, Spain), J. Borr{\`a}s, J. Galceran (Tarragona, Spain), J. de la B{\'a}rcena Guallar, M.C. Martos Jim{\'e}nez (Zaragoza, Spain); G. Jundt (Basel, Switzerland), C. Bouchardy, M. Usel (Geneva, Switzerland), T. Fisch, S. Ess (St Gallen Appenzell, Switzerland); C.A. Stiller, M.F.G. Murphy, G.J. Draper (England and Wales, UK), D. Brewster, L. Bhatti, A. McDonald (Scotland, UK). We also acknowledge the collaborators from the other registries participating in ACCIS, whose data were not included in this paper. ",
year = "2006",
month = sep,
day = "1",
doi = "10.1016/j.ejca.2006.05.006",
language = "English",
volume = "42",
pages = "1981--2005",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Elsevier Ltd.",
number = "13",
}
