@article{4696a8f7895e4075b9968c90f53c9a70,
title = "Transorbital Sonography and Visual Outcome for the Diagnosis and Monitoring of Optic Neuritis",
abstract = "BACKGROUND AND PURPOSE: Transorbital sonography (TOS) is a promising tool to support the clinical diagnosis of optic neuritis (ON) by showing thickening of optic nerve. In this study, we aimed to define its specific role in follow-up of ON patients. METHODS: We measured ultrasonography parameters and visual acuity (VA) at presentation and after 1 year in 45 patients with newly diagnosed ON. Two vascular sonographers used B-mode TOS to evaluate mean optic nerve diameter (OND) and optic nerve sheath diameter (ONSD). RESULTS: Median ONSD values were significantly thicker in patients with ON in the affected eye (6.4 mm, interquartile range [IQR]: 6.0-6.9) at presentation compared with the nonaffected side (5.7 mm; IQR: 5.2-6.1) (P <.001). The median OND was not significantly thicker at presentation in the affected eye (3.0 mm; IQR: 2.9-3.4) compared with the fellow eye (2.9 mm; IQR: 2.8-3.2) (P =.09). Logarithmic VA was significantly compromised at presentation in the affected eye (.16; IQR:.00–.55) compared with fellow eye (.00; IQR:.00–.00) (P <.001). After 1 year, no significant difference (P ≥.05) was found between ONSD or OND of the affected side compared with the nonaffected side. VA improved in most of the patients but remained significantly impaired in affected eye after 1 year. CONCLUSIONS: TOS is a useful tool to support diagnosis of ON. This technique seems to have less value to evaluate atrophy of the optic nerve after 12 months.",
keywords = "Optic nerve sheath diameter, optic disc elevation, optic nerve diameter, optic neuritis, transorbital sonography, visual acuity",
author = "Piergiorgio Lochner and Leone, \{Maurizio A.\} and Klaus Fassbender and Roberto Cantello and Lorenzo Coppo and Raffaele Nardone and Gianni Zorzi and Martin Lesmeister and Cristoforo Comi and Francesco Brigo",
note = "Publisher Copyright: Copyright {\textcopyright} 2016 by the American Society of Neuroimaging",
year = "2017",
month = jan,
day = "1",
doi = "10.1111/jon.12405",
language = "English",
volume = "27",
pages = "92--96",
journal = "Journal of Neuroimaging",
issn = "1051-2284",
publisher = "Wiley-Blackwell",
number = "1",
}