Transition-metal-free direct arylation of anilines

Tracey Pirali; Fengzhi Zhang; Anna H. Miller; Jenna L. Head; Donald McAusland; Michael F. Greaney

doi:10.1002/anie.201106150

Transition-metal-free direct arylation of anilines

Tracey Pirali
, Fengzhi Zhang
, Anna H. Miller
, Jenna L. Head
, Donald McAusland
, Michael F. Greaney

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Aryne arylation: A new method of direct arylation is reported for aniline substrates. The reaction uses benzyne to synthesize a variety of aminobiaryls under mild conditions (see scheme), requiring no stoichiometric metalation or transition-metal catalysis. An ene mechanism is implicated, and conveys excellent functional group tolerance relative to metal-mediated processes.

Lingua originale	Inglese
pagine (da-a)	1006-1009
Numero di pagine	4
Rivista	Angewandte Chemie - International Edition
Volume	51
Numero di pubblicazione	4
DOI	https://doi.org/10.1002/anie.201106150
Stato di pubblicazione	Pubblicato - 23 gen 2012

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10.1002/anie.201106150

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title = "Transition-metal-free direct arylation of anilines",

abstract = "Aryne arylation: A new method of direct arylation is reported for aniline substrates. The reaction uses benzyne to synthesize a variety of aminobiaryls under mild conditions (see scheme), requiring no stoichiometric metalation or transition-metal catalysis. An ene mechanism is implicated, and conveys excellent functional group tolerance relative to metal-mediated processes.",

keywords = "C-H bond activation, anilines, arynes",

author = "Tracey Pirali and Fengzhi Zhang and Miller, \{Anna H.\} and Head, \{Jenna L.\} and Donald McAusland and Greaney, \{Michael F.\}",

year = "2012",

month = jan,

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doi = "10.1002/anie.201106150",

language = "English",

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T1 - Transition-metal-free direct arylation of anilines

AU - Pirali, Tracey

AU - Zhang, Fengzhi

AU - Miller, Anna H.

AU - Head, Jenna L.

AU - McAusland, Donald

AU - Greaney, Michael F.

PY - 2012/1/23

Y1 - 2012/1/23

N2 - Aryne arylation: A new method of direct arylation is reported for aniline substrates. The reaction uses benzyne to synthesize a variety of aminobiaryls under mild conditions (see scheme), requiring no stoichiometric metalation or transition-metal catalysis. An ene mechanism is implicated, and conveys excellent functional group tolerance relative to metal-mediated processes.

AB - Aryne arylation: A new method of direct arylation is reported for aniline substrates. The reaction uses benzyne to synthesize a variety of aminobiaryls under mild conditions (see scheme), requiring no stoichiometric metalation or transition-metal catalysis. An ene mechanism is implicated, and conveys excellent functional group tolerance relative to metal-mediated processes.

KW - C-H bond activation

KW - anilines

KW - arynes

UR - https://www.scopus.com/pages/publications/84862945294

U2 - 10.1002/anie.201106150

DO - 10.1002/anie.201106150

M3 - Article

SN - 1433-7851

VL - 51

SP - 1006

EP - 1009

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 4

ER -

Transition-metal-free direct arylation of anilines

Abstract

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