TY - JOUR
T1 - Transition metal carbonyl clusters in biology
T2 - A futile or niche research area?
AU - Arrais, Aldo
AU - Gabano, Elisabetta
AU - Ravera, Mauro
AU - Osella, Domenico
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/1/30
Y1 - 2018/1/30
N2 - Transition metal carbonyl clusters (TMCCs) have seldom been considered in a biological perspective. Albeit generally flawed with low water-solubility and poor air-stability, drawbacks typical of all the organometallic complexes, selected TMCCs, designed by consolidated synthetic chemical routes, have so far encountered applications in few carefully selected biological fields, thus representing a very niche research area. This paper presents a brief overview of the applications of TMCCs in protein structural characterization, in hormone labelling, in carbonyl metallo-immunoassay (CMIA), as carbon monoxide releasing molecules (CORM) and, finally, as antiproliferative (antitumor) agents.
AB - Transition metal carbonyl clusters (TMCCs) have seldom been considered in a biological perspective. Albeit generally flawed with low water-solubility and poor air-stability, drawbacks typical of all the organometallic complexes, selected TMCCs, designed by consolidated synthetic chemical routes, have so far encountered applications in few carefully selected biological fields, thus representing a very niche research area. This paper presents a brief overview of the applications of TMCCs in protein structural characterization, in hormone labelling, in carbonyl metallo-immunoassay (CMIA), as carbon monoxide releasing molecules (CORM) and, finally, as antiproliferative (antitumor) agents.
KW - Antiproliferative agents
KW - Carbon monoxide releasing molecules
KW - Carbonyl metallo-immunoassay
KW - Protein structural characterization
KW - Transition metal carbonyl clusters
UR - http://www.scopus.com/inward/record.url?scp=85019383526&partnerID=8YFLogxK
U2 - 10.1016/j.ica.2017.05.021
DO - 10.1016/j.ica.2017.05.021
M3 - Review article
SN - 0020-1693
VL - 470
SP - 3
EP - 10
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
ER -