TY - JOUR
T1 - Tissue engineering in periodontology
T2 - Biological mediators for periodontal regeneration
AU - Carmagnola, Daniela
AU - Pellegrini, Gaia
AU - Dellavia, Claudia
AU - Rimondini, Lia
AU - Varoni, Elena
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Teeth and the periodontal tissues represent a highly specialized functional system. When periodontal disease occurs, the periodontal complex, composed by alveolar bone, root cementum, periodontal ligament, and gingiva, can be lost. Periodontal regenerative medicine aims at recovering damaged periodontal tissues and their functions by different means, including the interaction of bioactive molecules, cells, and scaffolds. The application of growth factors, in particular, into periodontal defects has shown encouraging effects, driving the wound healing toward the full, multi-tissue periodontal regeneration, in a precise temporal and spatial order. The aim of the present comprehensive review is to update the state of the art concerning tissue engineering in periodontology, focusing on biological mediators and gene therapy.
AB - Teeth and the periodontal tissues represent a highly specialized functional system. When periodontal disease occurs, the periodontal complex, composed by alveolar bone, root cementum, periodontal ligament, and gingiva, can be lost. Periodontal regenerative medicine aims at recovering damaged periodontal tissues and their functions by different means, including the interaction of bioactive molecules, cells, and scaffolds. The application of growth factors, in particular, into periodontal defects has shown encouraging effects, driving the wound healing toward the full, multi-tissue periodontal regeneration, in a precise temporal and spatial order. The aim of the present comprehensive review is to update the state of the art concerning tissue engineering in periodontology, focusing on biological mediators and gene therapy.
KW - Tissue engineering
KW - biological mediators
KW - gene therapy
KW - growth factors
KW - periodontal regeneration
KW - periodontology
UR - http://www.scopus.com/inward/record.url?scp=85063962084&partnerID=8YFLogxK
U2 - 10.1177/0391398819828558
DO - 10.1177/0391398819828558
M3 - Article
SN - 0391-3988
VL - 42
SP - 241
EP - 257
JO - International Journal of Artificial Organs
JF - International Journal of Artificial Organs
IS - 5
ER -