TY - JOUR
T1 - Time trends of cancer incidence in European children (1978-1997)
T2 - Report from the Automated Childhood Cancer Information System project
AU - Kaatsch, Peter
AU - Steliarova-Foucher, Eva
AU - Crocetti, Emanuele
AU - Magnani, Corrado
AU - Spix, Claudia
AU - Zambon, Paola
N1 - Funding Information:
The ACCIS project was funded by the European Commission from the Europe Against Cancer programme (contracts SI2.126875, SI2.321970 and SPC.2002303), jointly with International Agency for Research on Cancer (IARC). Data analyses were partly funded by the French Ligue Nationale Contre le Cancer, Comité du Rhône .
Funding Information:
The authors thank Nicolas Mitton for his input in the set-up and management and exploration of the ACCIS database, Melanie Kaiser, Mainz, for help in the preparation of the tables, the ACCIS Scientific Committee and the editors, in particular Charles Stiller, for helpful comments. Some of the data analyses and preparation of the manuscript were partly funded by the German Cancer Aid.
PY - 2006/9
Y1 - 2006/9
N2 - Within the framework of the Automated Childhood Cancer Information System (ACCIS), time trend analyses for childhood cancer were performed using data from 33 population-based cancer registries in 15 European countries for the period 1978-1997. The overall incidence rate based on 77,111 cases has increased significantly (P < 0.0001), with an average annual percentage change (AAPC) of 1.1%. The rising trend was observed in all five geographical regions and in the majority of the disease groups (in order of AAPC): soft tissue sarcomas (1.8%), brain tumours, tumours of the sympathetic nervous system, germ-cell tumours, carcinomas, lymphomas, renal tumours, and leukaemias (0.6%). No change was seen in incidence of bone tumours, hepatic tumours and retinoblastoma. The increased incidence can only partly be explained by changes in diagnostic methods and by registration artefacts. The patterns and magnitude of these increases suggest that other factors, e.g. changes in lifestyle and in exposure to a variety of agents, have contributed to the increase in childhood cancer in the recent decades.
AB - Within the framework of the Automated Childhood Cancer Information System (ACCIS), time trend analyses for childhood cancer were performed using data from 33 population-based cancer registries in 15 European countries for the period 1978-1997. The overall incidence rate based on 77,111 cases has increased significantly (P < 0.0001), with an average annual percentage change (AAPC) of 1.1%. The rising trend was observed in all five geographical regions and in the majority of the disease groups (in order of AAPC): soft tissue sarcomas (1.8%), brain tumours, tumours of the sympathetic nervous system, germ-cell tumours, carcinomas, lymphomas, renal tumours, and leukaemias (0.6%). No change was seen in incidence of bone tumours, hepatic tumours and retinoblastoma. The increased incidence can only partly be explained by changes in diagnostic methods and by registration artefacts. The patterns and magnitude of these increases suggest that other factors, e.g. changes in lifestyle and in exposure to a variety of agents, have contributed to the increase in childhood cancer in the recent decades.
KW - Cancer
KW - Childhood
KW - Epidemiology
KW - Europe
KW - Registry
KW - Time trends
UR - http://www.scopus.com/inward/record.url?scp=33747137225&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2006.05.014
DO - 10.1016/j.ejca.2006.05.014
M3 - Article
SN - 0959-8049
VL - 42
SP - 1961
EP - 1971
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 13
ER -
