TY - JOUR
T1 - Time trends and prognostic factors for survival from childhood cancer
T2 - A report from the Childhood Cancer Registry of Piedmont (Italy)
AU - Dama, Elisa
AU - Pastore, Guido
AU - Mosso, Maria Luisa
AU - Maule, Milena Maria
AU - Zuccolo, Luisa
AU - Magnani, Corrado
AU - Merletti, Franco
N1 - Funding Information:
Acknowledgements The CCRP is supported by the Piedmont Region. This project was partly supported by the “Oncology Special Project”, Compagnia di San Paolo FIRMS, by the Italian Association for Research on Cancer (AIRC), by the special program “Ricerca Sanitaria Finalizzata” of the Piedmont Region and by “University of Eastern Piedmont, local research funds 2003”. We thank Prof. Benedetto Terracini and Prof. Neil Pearce for their insight and for reading the manuscript. We thank Prof. Giuseppe Masera, Prof. Modesto Carli, Prof. Enrico Madon, Prof. Andrea Pession, Dr. Bruno De Bernardi and Dr. Franca Fossati Bellani, chairmen of AIEOP protocols, and Dr Roberto Rondelli for supplying clinical data. A grateful thanks to Mrs. Marinella Nonnato for the careful management of the CCRP data and for the follow-up.
PY - 2006/4
Y1 - 2006/4
N2 - Survival after childhood cancer has been improving since the late 1970s in most developed countries. The Childhood Cancer Registry of Piedmont has been recording malignant tumors in children (0-14 years) throughout Piedmont since 1967. The present paper is based on the records of the 2,970 children diagnosed during the period 1970-2001; survival rates are estimated up to June 30, 2004. Based on records from the Registrar Offices of the relevant towns of residence, 1,698 children were reported to be alive, 1,252 deceased, and 20 were of unknown vital status. Over the period 1970-2001, 5-year survival rates for all tumor types combined showed a statistically significant increasing trend (p<0.0001). For acute lymphocytic leukemia, the survival rate increased steadily from 24.7% (95% CI 15.0-34.3) in 1970-1974 to 87.8% (82.1-93.6) in 1995-1999. Five-year survival rates for central nervous system tumors increased from 32.8% (21.0-44.6) in 1970-1974 to 80.3% (72.6-88.0) in 1990-1994 and decreased thereafter. Age of less than 1 year at time of diagnosis was a favorable prognostic factor for neuroblastoma and ganglioneuroblastoma. The extent of disease at diagnosis was related to prognosis for neuroblastoma and ganglioneuroblastoma and other selected solid tumors. A white blood cell count greater than 50,000×106 cells/l was associated with decreased survival in children with acute lymphocytic leukemia and acute non-lymphocytic leukemia. We have found positive trends in survival for all tumor types in Piedmont, similar to those reported by other population-based cancer registries. Age, extent of disease, and white blood cell count at diagnosis are prognostic factors for selected cancer sites.
AB - Survival after childhood cancer has been improving since the late 1970s in most developed countries. The Childhood Cancer Registry of Piedmont has been recording malignant tumors in children (0-14 years) throughout Piedmont since 1967. The present paper is based on the records of the 2,970 children diagnosed during the period 1970-2001; survival rates are estimated up to June 30, 2004. Based on records from the Registrar Offices of the relevant towns of residence, 1,698 children were reported to be alive, 1,252 deceased, and 20 were of unknown vital status. Over the period 1970-2001, 5-year survival rates for all tumor types combined showed a statistically significant increasing trend (p<0.0001). For acute lymphocytic leukemia, the survival rate increased steadily from 24.7% (95% CI 15.0-34.3) in 1970-1974 to 87.8% (82.1-93.6) in 1995-1999. Five-year survival rates for central nervous system tumors increased from 32.8% (21.0-44.6) in 1970-1974 to 80.3% (72.6-88.0) in 1990-1994 and decreased thereafter. Age of less than 1 year at time of diagnosis was a favorable prognostic factor for neuroblastoma and ganglioneuroblastoma. The extent of disease at diagnosis was related to prognosis for neuroblastoma and ganglioneuroblastoma and other selected solid tumors. A white blood cell count greater than 50,000×106 cells/l was associated with decreased survival in children with acute lymphocytic leukemia and acute non-lymphocytic leukemia. We have found positive trends in survival for all tumor types in Piedmont, similar to those reported by other population-based cancer registries. Age, extent of disease, and white blood cell count at diagnosis are prognostic factors for selected cancer sites.
KW - Cancer registries
KW - Childhood neoplasm
KW - Population based studies
KW - Prognostic factors
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=33344472561&partnerID=8YFLogxK
U2 - 10.1007/s00431-005-0034-7
DO - 10.1007/s00431-005-0034-7
M3 - Article
SN - 0340-6199
VL - 165
SP - 240
EP - 249
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 4
ER -
