TY - JOUR
T1 - Thymoma and inter-relationships between clinical variables
T2 - A multicentre study in 537 patients
AU - Filosso, Pier Luigi
AU - Venuta, Federico
AU - Oliaro, Alberto
AU - Ruffini, Enrico
AU - Rendina, Erino Angelo
AU - Margaritora, Stefano
AU - Casadio, Caterina
AU - Terzi, Alberto
AU - Rena, Ottavio
AU - Lococo, Filippo
AU - Guerrera, Francesco
PY - 2014/2
Y1 - 2014/2
N2 - OBJECTIVES: In thymomas, the roles of Masaoka-Koga stage, histology and the presence of myasthenia gravis (MG) have been considered fundamental for patient management and outcomes. In this study, we retrospectively evaluated several clinical variables, with the aim of outlining their relationships and clinical/prognostic significance in resected thymoma patients. METHODS: A retrospective search of our surgical database for patients operated on for thymoma in six Italian high-volume thoracic surgery centres between 2000 and 2011 was conducted. The following clinical variables were evaluated: Masaoka-Koga Stage, tumour histology, the presence of MG, other autoimmune syndromes or second tumours, the completeness of tumour resection and the development of recurrences. RESULTS: Five hundred and thirty-seven (273 males-51%) were retrospectively included in this study. Our results indicate that: (i) MG correlates with early Masaoka-Koga stage and B-type thymoma; (ii) Stage III-IVa tumours correlate with B-type tumour; (iii) autoimmune paraneoplastic syndromes correlate with Stage I-II thymoma; (iv) second malignancies correlate with the absence of paraneoplastic disorders and weakly with B-type tumour and (v) overall survival was influenced by Masaoka-Koga stage and completeness of surgical resection. CONCLUSIONS: In thymomas, Masaoka-Koga stage, histology, MG, other autoimmune syndromes and second malignancies are inter-related, but only Masaoka-Koga tumour stage, amid these clinical variables, has been demonstrated to be a strong prognostic indicator of survival.
AB - OBJECTIVES: In thymomas, the roles of Masaoka-Koga stage, histology and the presence of myasthenia gravis (MG) have been considered fundamental for patient management and outcomes. In this study, we retrospectively evaluated several clinical variables, with the aim of outlining their relationships and clinical/prognostic significance in resected thymoma patients. METHODS: A retrospective search of our surgical database for patients operated on for thymoma in six Italian high-volume thoracic surgery centres between 2000 and 2011 was conducted. The following clinical variables were evaluated: Masaoka-Koga Stage, tumour histology, the presence of MG, other autoimmune syndromes or second tumours, the completeness of tumour resection and the development of recurrences. RESULTS: Five hundred and thirty-seven (273 males-51%) were retrospectively included in this study. Our results indicate that: (i) MG correlates with early Masaoka-Koga stage and B-type thymoma; (ii) Stage III-IVa tumours correlate with B-type tumour; (iii) autoimmune paraneoplastic syndromes correlate with Stage I-II thymoma; (iv) second malignancies correlate with the absence of paraneoplastic disorders and weakly with B-type tumour and (v) overall survival was influenced by Masaoka-Koga stage and completeness of surgical resection. CONCLUSIONS: In thymomas, Masaoka-Koga stage, histology, MG, other autoimmune syndromes and second malignancies are inter-related, but only Masaoka-Koga tumour stage, amid these clinical variables, has been demonstrated to be a strong prognostic indicator of survival.
KW - Cancer
KW - Myasthenia gravis
KW - Paraneoplastic disorders
KW - Pathology
KW - Surgery
KW - Thymoma
KW - World Health Organization
UR - http://www.scopus.com/inward/record.url?scp=84900558514&partnerID=8YFLogxK
U2 - 10.1093/ejcts/ezt567
DO - 10.1093/ejcts/ezt567
M3 - Article
SN - 1010-7940
VL - 45
SP - 1020
EP - 1027
JO - European Journal of Cardio-thoracic Surgery
JF - European Journal of Cardio-thoracic Surgery
IS - 6
M1 - ezt567
ER -