The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review

Hannah M. Dahn; Liesbeth J. Boersma; Dirk de Ruysscher; Icro Meattini; Birgitte V. Offersen; Jean Philippe Pignol; Cynthia Aristei; Yazid Belkacemi; Dori Benjamin; Nuran Bese; Charlotte E. Coles; Pierfrancesco Franco; Alice Ho; Sandra Hol; Reshma Jagsi; Anna M. Kirby; Livia Marrazzo; Gustavo N. Marta; Meena S. Moran; Alan M. Nichol; Henrik D. Nissen; Vratislav Strnad; Yvonne E. Zissiadis; Philip Poortmans; Orit Kaidar-Person

doi:10.1016/j.critrevonc.2021.103391

The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review

Hannah M. Dahn, Liesbeth J. Boersma, Dirk de Ruysscher, Icro Meattini, Birgitte V. Offersen, Jean Philippe Pignol, Cynthia Aristei, Yazid Belkacemi, Dori Benjamin, Nuran Bese, Charlotte E. Coles, Pierfrancesco Franco, Alice Ho, Sandra Hol, Reshma Jagsi, Anna M. Kirby, Livia Marrazzo, Gustavo N. Marta, Meena S. Moran, Alan M. NicholHenrik D. Nissen, Vratislav Strnad, Yvonne E. Zissiadis, Philip Poortmans, Orit Kaidar-Person

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo di review › peer review

Abstract

Purpose: Post mastectomy radiation therapy (PMRT) reduces locoregional recurrence (LRR) and breast cancer mortality for selected patients. Bolus overcomes the skin-sparing effect of external-beam radiotherapy, ensuring adequate dose to superficial regions at risk of local recurrence (LR). This systematic review summarizes the current evidence regarding the impact of bolus on LR and acute toxicity in the setting of PMRT. Results: 27 studies were included. The use of bolus led to higher rates of acute grade 3 radiation dermatitis (pooled rates of 9.6% with bolus vs. 1.2% without). Pooled crude LR rates from thirteen studies (n = 3756) were similar with (3.5%) and without (3.6%) bolus. Conclusions: Bolus may be indicated in cases with a high risk of LR in the skin, but seems not to be necessary for all patients. Further work is needed to define the role of bolus in PMRT.

Lingua originale	Inglese
Numero di articolo	103391
Rivista	Critical Reviews in Oncology/Hematology
Volume	163
DOI	https://doi.org/10.1016/j.critrevonc.2021.103391
Stato di pubblicazione	Pubblicato - lug 2021

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10.1016/j.critrevonc.2021.103391

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Dahn, H. M., Boersma, L. J., de Ruysscher, D., Meattini, I., Offersen, B. V., Pignol, J. P., Aristei, C., Belkacemi, Y., Benjamin, D., Bese, N., Coles, C. E., Franco, P., Ho, A., Hol, S., Jagsi, R., Kirby, A. M., Marrazzo, L., Marta, G. N., Moran, M. S., ... Kaidar-Person, O. (2021). The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review. Critical Reviews in Oncology/Hematology, 163, Articolo 103391. https://doi.org/10.1016/j.critrevonc.2021.103391

@article{7415b5cc89c44950abc2808b8e05d5da,

title = "The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review",

abstract = "Purpose: Post mastectomy radiation therapy (PMRT) reduces locoregional recurrence (LRR) and breast cancer mortality for selected patients. Bolus overcomes the skin-sparing effect of external-beam radiotherapy, ensuring adequate dose to superficial regions at risk of local recurrence (LR). This systematic review summarizes the current evidence regarding the impact of bolus on LR and acute toxicity in the setting of PMRT. Results: 27 studies were included. The use of bolus led to higher rates of acute grade 3 radiation dermatitis (pooled rates of 9.6% with bolus vs. 1.2% without). Pooled crude LR rates from thirteen studies (n = 3756) were similar with (3.5%) and without (3.6%) bolus. Conclusions: Bolus may be indicated in cases with a high risk of LR in the skin, but seems not to be necessary for all patients. Further work is needed to define the role of bolus in PMRT.",

keywords = "PMRT, bolus, breast cancer, mastectomy, post-mastectomy, radiation therapy, tissue compensator",

author = "Dahn, {Hannah M.} and Boersma, {Liesbeth J.} and {de Ruysscher}, Dirk and Icro Meattini and Offersen, {Birgitte V.} and Pignol, {Jean Philippe} and Cynthia Aristei and Yazid Belkacemi and Dori Benjamin and Nuran Bese and Coles, {Charlotte E.} and Pierfrancesco Franco and Alice Ho and Sandra Hol and Reshma Jagsi and Kirby, {Anna M.} and Livia Marrazzo and Marta, {Gustavo N.} and Moran, {Meena S.} and Nichol, {Alan M.} and Nissen, {Henrik D.} and Vratislav Strnad and Zissiadis, {Yvonne E.} and Philip Poortmans and Orit Kaidar-Person",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = jul,

doi = "10.1016/j.critrevonc.2021.103391",

language = "English",

volume = "163",

journal = "Critical Reviews in Oncology/Hematology",

issn = "1040-8428",

publisher = "Elsevier Ireland Ltd",

}

Dahn, HM, Boersma, LJ, de Ruysscher, D, Meattini, I, Offersen, BV, Pignol, JP, Aristei, C, Belkacemi, Y, Benjamin, D, Bese, N, Coles, CE, Franco, P, Ho, A, Hol, S, Jagsi, R, Kirby, AM, Marrazzo, L, Marta, GN, Moran, MS, Nichol, AM, Nissen, HD, Strnad, V, Zissiadis, YE, Poortmans, P & Kaidar-Person, O 2021, 'The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review', Critical Reviews in Oncology/Hematology, vol. 163, 103391. https://doi.org/10.1016/j.critrevonc.2021.103391

TY - JOUR

T1 - The use of bolus in postmastectomy radiation therapy for breast cancer

T2 - A systematic review

AU - Dahn, Hannah M.

AU - Boersma, Liesbeth J.

AU - de Ruysscher, Dirk

AU - Meattini, Icro

AU - Offersen, Birgitte V.

AU - Pignol, Jean Philippe

AU - Aristei, Cynthia

AU - Belkacemi, Yazid

AU - Benjamin, Dori

AU - Bese, Nuran

AU - Coles, Charlotte E.

AU - Franco, Pierfrancesco

AU - Ho, Alice

AU - Hol, Sandra

AU - Jagsi, Reshma

AU - Kirby, Anna M.

AU - Marrazzo, Livia

AU - Marta, Gustavo N.

AU - Moran, Meena S.

AU - Nichol, Alan M.

AU - Nissen, Henrik D.

AU - Strnad, Vratislav

AU - Zissiadis, Yvonne E.

AU - Poortmans, Philip

AU - Kaidar-Person, Orit

PY - 2021/7

Y1 - 2021/7

N2 - Purpose: Post mastectomy radiation therapy (PMRT) reduces locoregional recurrence (LRR) and breast cancer mortality for selected patients. Bolus overcomes the skin-sparing effect of external-beam radiotherapy, ensuring adequate dose to superficial regions at risk of local recurrence (LR). This systematic review summarizes the current evidence regarding the impact of bolus on LR and acute toxicity in the setting of PMRT. Results: 27 studies were included. The use of bolus led to higher rates of acute grade 3 radiation dermatitis (pooled rates of 9.6% with bolus vs. 1.2% without). Pooled crude LR rates from thirteen studies (n = 3756) were similar with (3.5%) and without (3.6%) bolus. Conclusions: Bolus may be indicated in cases with a high risk of LR in the skin, but seems not to be necessary for all patients. Further work is needed to define the role of bolus in PMRT.

AB - Purpose: Post mastectomy radiation therapy (PMRT) reduces locoregional recurrence (LRR) and breast cancer mortality for selected patients. Bolus overcomes the skin-sparing effect of external-beam radiotherapy, ensuring adequate dose to superficial regions at risk of local recurrence (LR). This systematic review summarizes the current evidence regarding the impact of bolus on LR and acute toxicity in the setting of PMRT. Results: 27 studies were included. The use of bolus led to higher rates of acute grade 3 radiation dermatitis (pooled rates of 9.6% with bolus vs. 1.2% without). Pooled crude LR rates from thirteen studies (n = 3756) were similar with (3.5%) and without (3.6%) bolus. Conclusions: Bolus may be indicated in cases with a high risk of LR in the skin, but seems not to be necessary for all patients. Further work is needed to define the role of bolus in PMRT.

KW - PMRT

KW - bolus

KW - breast cancer

KW - mastectomy

KW - post-mastectomy

KW - radiation therapy

KW - tissue compensator

UR - http://www.scopus.com/inward/record.url?scp=85107968598&partnerID=8YFLogxK

U2 - 10.1016/j.critrevonc.2021.103391

DO - 10.1016/j.critrevonc.2021.103391

M3 - Review article

SN - 1040-8428

VL - 163

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

M1 - 103391

ER -

The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review

Abstract

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