The transcriptomic analysis of nsc-34 motor neuron-like cells reveals that cannabigerol influences synaptic pathways: A comparative study with cannabidiol

Agnese Gugliandolo, Serena Silvestro, Luigi Chiricosta, Federica Pollastro, Placido Bramanti, Emanuela Mazzon

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

More than 120 cannabinoids were isolated from Cannabis sativa. In particular, Cannabidiol (CBD) and Cannabigerol (CBG) represent the two most studied non-psychoactive cannabinoids. However, CBG is less studied and less data are available on its biological properties and influence on synaptic transmission. On the contrary, CBD is already known to modulate brain excitatory glutamate, inhibitory γ-aminobutyric acid (GABA) and dopamine neurotransmission. In this study, using Next-Generation Sequencing (NGS) technology, we evaluated how CBG (1 or 5 µM) and CBD (1 or 5 µM) influence the transcriptome of the main neurotransmission pathways in NSC-34 motor neuron-like cells. At first, we evaluated that CBG and CBD were not cytotoxic and decreased the expression of pro-apoptotic genes. CBG and CBD are able to influence the expression of the genes involved in glutamate, GABA and dopamine signaling. Interestingly, the transcriptional changes induced by CBG were similar compared to CBD.

Lingua originaleInglese
Numero di articolo227
pagine (da-a)1-18
Numero di pagine18
RivistaLife
Volume10
Numero di pubblicazione10
DOI
Stato di pubblicazionePubblicato - ott 2020

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