The role of plasma fibronectin in platelet adhesion to collagen

C. L. Balduini, F. Sinigaglia, P. Salvini, C. Balduini

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Human washed platelets were eluted from columns of Sepharose 4B linked to different preparations of collagen in order to evaluate cell adhesion. Collagen preparations characterized by low and high affinity toward platelets were identified. In our experiments, fibronectin purified from human plasma modified platelet adhesiveness, though not dramatically. When washed platelets, resuspended in a buffer containing fibronectin, were filtered on a low-affinity collagen-Sepharose, a significant increase in their adhesion occurred. A similar modification could be observed when platelets were allowed to adhere to the same collagen-Sepharose preconditioned with fibronectin, The effect of fibronectin was otherwise negligible when the high-affinity collagen was used for the experiments.

Lingua originaleInglese
pagine (da-a)158-163
Numero di pagine6
RivistaHaemostasis
Volume14
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 1984
Pubblicato esternamente

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