TY - JOUR
T1 - The role of cytokines in the pathogenesis and management of aids-related lymphomas
AU - Fassone, Lucia
AU - Gaidano, Gianluca
AU - Ariatti, Cristiano
AU - Vivenza, Daniela
AU - Capello, Daniela
AU - Gloghini, Annunziata
AU - Cilia, Anna Maria
AU - Buonaiuto, Daniela
AU - Rossi, Davide
AU - Pastore, Cristina
AU - Carbone, Antonino
AU - Saglio, Giuseppe
N1 - Funding Information:
Supported by: Istituto Superiore di Sanita, I1 Programma Nazionale di Ricerca sull’AIDS 1998 - Pro-getto Patologia, Clinica e Terapia dell’AIDS. Rome, Italy; Fondazione “Piera Pietro e Giovanni Ferrero”, Alba, Italy; and “Fondazione CRT”, Torino, Italy. D.C. is being supported by a fellowship from AIRC. Milan, Italy. L.F. is being supported by the PhD program in Molecular Medicine of the Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
PY - 2000
Y1 - 2000
N2 - AIDS-related non-Hodgkin lymphomas (AIDS-NHL) consistently derive from B-cells and are characterized by extreme clinical aggressiveness. At histological level, AIDS-NHL are classified as AIDS-related Burkitt's lymphoma (AIDS-BL), AIDS-related diffuse large cell lymphoma (AIDS-DLCL) and AIDS-related primary effusion lymphoma (AIDS-PEL). The role of cytokines in the pathogenesis and management of AIDS-NHL has been studied to a certain extent. Production of large quantities of human IL-10 occurs frequently in AIDS-BL and correlates with latent EBV infection of the tumor clone. Lesser amounts of the cytokine are released in EBV negative cases. The pathogenetic role of IL-10 in AIDS-BL is suggested by the observation that IL-10 antisense oligonucleotides inhibit proliferation of the lymphoma. A significan fraction of AIDS-BL cell lines produce TNFβ. Among AIDS-NHL, the release of TNFβ appears to be specific for AIDS-BL. The pathogenetic relevance of TNFβ in lymphomagenesis is suggested by the observation that some BL cell lines use TNFP as an autocrine growth factor. Some cases of AIDS-BL, particularly those carrying EBV infection, also secrete IL-6, IL-7 and IL-12. With respect to AIDS-DLCL, many cases express the IL-6R, rendering these cells responsive to the paracrine stimulation by the IL-6 produced by nearby T-cells, macrophages and endothelial cells which are frequently abundant in these tumor samples. The tumor clone itself, however, generally fails to release IL-6. AIDS-PEL is characterized by secretion of large amounts of IL-6 and IL-10. Some PEL cases also release oncostatin M. Apart from human IL,-6, PEL also express viral IL-6, which is encoded by the HHV-8 genome. The biological relevance of both IL-6 and IL-10 in PEL proliferation and growth has been recently clarified in vitro and in vivo. Overall, these data suggest that activation of different cytokine loops clusters with different clinico-pathologic categories of AIDS-NHL and may represent the potential target of novel therapeutic strategies.
AB - AIDS-related non-Hodgkin lymphomas (AIDS-NHL) consistently derive from B-cells and are characterized by extreme clinical aggressiveness. At histological level, AIDS-NHL are classified as AIDS-related Burkitt's lymphoma (AIDS-BL), AIDS-related diffuse large cell lymphoma (AIDS-DLCL) and AIDS-related primary effusion lymphoma (AIDS-PEL). The role of cytokines in the pathogenesis and management of AIDS-NHL has been studied to a certain extent. Production of large quantities of human IL-10 occurs frequently in AIDS-BL and correlates with latent EBV infection of the tumor clone. Lesser amounts of the cytokine are released in EBV negative cases. The pathogenetic role of IL-10 in AIDS-BL is suggested by the observation that IL-10 antisense oligonucleotides inhibit proliferation of the lymphoma. A significan fraction of AIDS-BL cell lines produce TNFβ. Among AIDS-NHL, the release of TNFβ appears to be specific for AIDS-BL. The pathogenetic relevance of TNFβ in lymphomagenesis is suggested by the observation that some BL cell lines use TNFP as an autocrine growth factor. Some cases of AIDS-BL, particularly those carrying EBV infection, also secrete IL-6, IL-7 and IL-12. With respect to AIDS-DLCL, many cases express the IL-6R, rendering these cells responsive to the paracrine stimulation by the IL-6 produced by nearby T-cells, macrophages and endothelial cells which are frequently abundant in these tumor samples. The tumor clone itself, however, generally fails to release IL-6. AIDS-PEL is characterized by secretion of large amounts of IL-6 and IL-10. Some PEL cases also release oncostatin M. Apart from human IL,-6, PEL also express viral IL-6, which is encoded by the HHV-8 genome. The biological relevance of both IL-6 and IL-10 in PEL proliferation and growth has been recently clarified in vitro and in vivo. Overall, these data suggest that activation of different cytokine loops clusters with different clinico-pathologic categories of AIDS-NHL and may represent the potential target of novel therapeutic strategies.
KW - AIDS
KW - Cytokine
KW - Lymphoma
KW - Pathogenesis
UR - http://www.scopus.com/inward/record.url?scp=0033860905&partnerID=8YFLogxK
U2 - 10.3109/10428190009059266
DO - 10.3109/10428190009059266
M3 - Review article
SN - 1042-8194
VL - 38
SP - 481
EP - 488
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 5-6
ER -
