Abstract
The retro-aldol reductive fragmentation of different structural types of 7-hydroxy-9,10-dioxotaxoids was investigated, showing that the reaction is typical of taxanes and requires cerium(III) promotion with NaBH4 in protic medium and alkylboron (aluminium) hydrides in aprotic solvents. The resulting 7,8-seco-taxanes are key intermediates for the synthesis of a novel class of anticancer taxanes endowed with a unique pattern of in vivo biological activity.
Lingua originale | Inglese |
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pagine (da-a) | 4422-4431 |
Numero di pagine | 10 |
Rivista | European Journal of Organic Chemistry |
Numero di pubblicazione | 22 |
DOI | |
Stato di pubblicazione | Pubblicato - 14 nov 2003 |
Pubblicato esternamente | Sì |