The prognostic value of basal DNA damage level in peripheral blood lymphocytes of patients affected by bladder cancer

ALESSANDRA ALLIONE; Barbara Pardini; Clara Viberti; Marco Oderda; Marco Allasia; Paolo Gontero; Paolo Vineis; Carlotta SACERDOTE; Giuseppe Matullo

doi:10.1016/j.urolonc.2018.01.006

The prognostic value of basal DNA damage level in peripheral blood lymphocytes of patients affected by bladder cancer

ALESSANDRA ALLIONE, Barbara Pardini, Clara Viberti, Marco Oderda, Marco Allasia, Paolo Gontero, Paolo Vineis, Carlotta SACERDOTE, Giuseppe Matullo

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Bladder cancer (BC) is one of the most aggressive malignancies of the urinary tract, with the highest lifetime treatment costs per patient of all cancers, due to the high rate of recurrences requiring continuous surveillance. An early diagnosis is essential to improve survival of patients with BC. Noninvasive and sensitive molecular biomarkers are needed to improve current strategies for the detection and monitoring of BC. Previous studies suggested that elevated DNA damage levels and suboptimal nucleotide excision DNA repair (NER) may be associated with BC.

Lingua originale	Inglese
pagine (da-a)	1-9
Numero di pagine	9
Rivista	UROLOGIC ONCOLOGY
DOI	https://doi.org/10.1016/j.urolonc.2018.01.006
Stato di pubblicazione	Pubblicato - 2018

Keywords

Bladder cancer
Comet assay
DNA damage
DNA repair

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10.1016/j.urolonc.2018.01.006

https://hdl.handle.net/11579/176956

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title = "The prognostic value of basal DNA damage level in peripheral blood lymphocytes of patients affected by bladder cancer",

abstract = "Bladder cancer (BC) is one of the most aggressive malignancies of the urinary tract, with the highest lifetime treatment costs per patient of all cancers, due to the high rate of recurrences requiring continuous surveillance. An early diagnosis is essential to improve survival of patients with BC. Noninvasive and sensitive molecular biomarkers are needed to improve current strategies for the detection and monitoring of BC. Previous studies suggested that elevated DNA damage levels and suboptimal nucleotide excision DNA repair (NER) may be associated with BC.",

keywords = "Bladder cancer, Comet assay, DNA damage, DNA repair, Bladder cancer, Comet assay, DNA damage, DNA repair",

author = "ALESSANDRA ALLIONE and Barbara Pardini and Clara Viberti and Marco Oderda and Marco Allasia and Paolo Gontero and Paolo Vineis and Carlotta SACERDOTE and Giuseppe Matullo",

year = "2018",

doi = "10.1016/j.urolonc.2018.01.006",

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journal = "UROLOGIC ONCOLOGY",

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T1 - The prognostic value of basal DNA damage level in peripheral blood lymphocytes of patients affected by bladder cancer

AU - ALLIONE, ALESSANDRA

AU - Pardini, Barbara

AU - Viberti, Clara

AU - Oderda, Marco

AU - Allasia, Marco

AU - Gontero, Paolo

AU - Vineis, Paolo

AU - SACERDOTE, Carlotta

AU - Matullo, Giuseppe

PY - 2018

Y1 - 2018

N2 - Bladder cancer (BC) is one of the most aggressive malignancies of the urinary tract, with the highest lifetime treatment costs per patient of all cancers, due to the high rate of recurrences requiring continuous surveillance. An early diagnosis is essential to improve survival of patients with BC. Noninvasive and sensitive molecular biomarkers are needed to improve current strategies for the detection and monitoring of BC. Previous studies suggested that elevated DNA damage levels and suboptimal nucleotide excision DNA repair (NER) may be associated with BC.

AB - Bladder cancer (BC) is one of the most aggressive malignancies of the urinary tract, with the highest lifetime treatment costs per patient of all cancers, due to the high rate of recurrences requiring continuous surveillance. An early diagnosis is essential to improve survival of patients with BC. Noninvasive and sensitive molecular biomarkers are needed to improve current strategies for the detection and monitoring of BC. Previous studies suggested that elevated DNA damage levels and suboptimal nucleotide excision DNA repair (NER) may be associated with BC.

KW - Bladder cancer

KW - Comet assay

KW - DNA damage

KW - DNA repair

KW - Bladder cancer

KW - Comet assay

KW - DNA damage

KW - DNA repair

UR - https://iris.uniupo.it/handle/11579/176956

U2 - 10.1016/j.urolonc.2018.01.006

DO - 10.1016/j.urolonc.2018.01.006

M3 - Article

SN - 1078-1439

SP - 1

EP - 9

JO - UROLOGIC ONCOLOGY

JF - UROLOGIC ONCOLOGY

ER -

The prognostic value of basal DNA damage level in peripheral blood lymphocytes of patients affected by bladder cancer

Abstract

Keywords

OSS delle Nazioni Unite

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