The metabolic fate of the anti-Parkinsonian drug budipine in rats

O. Caputo; G. Grosa; M. Ceruti; F. Rocco; G. Biglino

doi:10.1007/BF03189947

The metabolic fate of the anti-Parkinsonian drug budipine in rats

O. Caputo, G. Grosa, M. Ceruti, F. Rocco, G. Biglino

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The metabolic fate of the anti-Parkinsonian drug budipine was studied in rats after oral administration. The presence of an aromatic hydroxylation product, metabolite Mi, and its O-sulphate conjugate was confirmed. Three new minor metabolites, budipine N-oxide, metabolite M₁ N-oxide and a secondary metabolite derived from M₁ via hydroxylation of a methyl of the tert-butyl group, were isolated and identified in rat urine. The presence of a metabolite M₁-glucuronic acid conjugate, was also established through different enzymatic treatments of the rat urine.

Lingua originale	Inglese
pagine (da-a)	113-118
Numero di pagine	6
Rivista	European Journal of Drug Metabolism and Pharmacokinetics
Volume	16
Numero di pubblicazione	2
DOI	https://doi.org/10.1007/BF03189947
Stato di pubblicazione	Pubblicato - apr 1991
Pubblicato esternamente	Sì

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title = "The metabolic fate of the anti-Parkinsonian drug budipine in rats",

abstract = "The metabolic fate of the anti-Parkinsonian drug budipine was studied in rats after oral administration. The presence of an aromatic hydroxylation product, metabolite Mi, and its O-sulphate conjugate was confirmed. Three new minor metabolites, budipine N-oxide, metabolite M1 N-oxide and a secondary metabolite derived from M1 via hydroxylation of a methyl of the tert-butyl group, were isolated and identified in rat urine. The presence of a metabolite M1-glucuronic acid conjugate, was also established through different enzymatic treatments of the rat urine.",

keywords = "1-tert-butyl-4,4-diphenylpiperidine, BY-701, Budipine, anti-Parkinsonian, metabolism",

author = "O. Caputo and G. Grosa and M. Ceruti and F. Rocco and G. Biglino",

year = "1991",

month = apr,

doi = "10.1007/BF03189947",

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journal = "European Journal of Drug Metabolism and Pharmacokinetics",

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T1 - The metabolic fate of the anti-Parkinsonian drug budipine in rats

AU - Caputo, O.

AU - Grosa, G.

AU - Ceruti, M.

AU - Rocco, F.

AU - Biglino, G.

PY - 1991/4

Y1 - 1991/4

N2 - The metabolic fate of the anti-Parkinsonian drug budipine was studied in rats after oral administration. The presence of an aromatic hydroxylation product, metabolite Mi, and its O-sulphate conjugate was confirmed. Three new minor metabolites, budipine N-oxide, metabolite M1 N-oxide and a secondary metabolite derived from M1 via hydroxylation of a methyl of the tert-butyl group, were isolated and identified in rat urine. The presence of a metabolite M1-glucuronic acid conjugate, was also established through different enzymatic treatments of the rat urine.

AB - The metabolic fate of the anti-Parkinsonian drug budipine was studied in rats after oral administration. The presence of an aromatic hydroxylation product, metabolite Mi, and its O-sulphate conjugate was confirmed. Three new minor metabolites, budipine N-oxide, metabolite M1 N-oxide and a secondary metabolite derived from M1 via hydroxylation of a methyl of the tert-butyl group, were isolated and identified in rat urine. The presence of a metabolite M1-glucuronic acid conjugate, was also established through different enzymatic treatments of the rat urine.

KW - 1-tert-butyl-4,4-diphenylpiperidine

KW - BY-701

KW - Budipine

KW - anti-Parkinsonian

KW - metabolism

UR - https://www.scopus.com/pages/publications/0025916840

U2 - 10.1007/BF03189947

DO - 10.1007/BF03189947

M3 - Article

SN - 0378-7966

VL - 16

SP - 113

EP - 118

JO - European Journal of Drug Metabolism and Pharmacokinetics

JF - European Journal of Drug Metabolism and Pharmacokinetics

IS - 2

ER -

The metabolic fate of the anti-Parkinsonian drug budipine in rats

Abstract

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