TY - JOUR
T1 - The influence of the gut-brain axis on anxiety and depression
T2 - A review of the literature on the use of probiotics
AU - Ferrari, Sara
AU - Mulè, Simone
AU - Parini, Francesca
AU - Galla, Rebecca
AU - Ruga, Sara
AU - Rosso, Giorgia
AU - Brovero, Arianna
AU - Molinari, Claudio
AU - Uberti, Francesca
N1 - Publisher Copyright:
© 2024 Center for Food and Biomolecules, National Taiwan University
PY - 2024/5
Y1 - 2024/5
N2 - This review aims to argue how using probiotics can improve anxiety and depressive behaviour without adverse effects, also exploring the impact of postbiotics on it. Specifically, probiotics have drawn more attention as effective alternative treatments, considering the rising cost of antidepressant and anti-anxiety drugs and the high risk of side effects. Depression and anxiety disorders are among the most common mental illnesses in the world's population, characterised by low mood, poor general interest, and cognitive or motor dysfunction. Thus, this study analysed published literature on anxiety, depression, and probiotic supplementation from PubMed and Scopus, focusing on the last twenty years. This study focused on the effect of probiotics on mental health as they have drawn more attention because of their extensive clinical applications and positive impact on various diseases. Numerous studies have demonstrated how the gut microbiota might be critical for mood regulation and how probiotics can affect host health by regulating the gut-brain axis. By comparing the different works analysed, it was possible to identify a strategy by which they are selected and employed and, at the same time, to assess how the effect of probiotics can be optimised using postbiotics, an innovation to improve mental well-being in humans.
AB - This review aims to argue how using probiotics can improve anxiety and depressive behaviour without adverse effects, also exploring the impact of postbiotics on it. Specifically, probiotics have drawn more attention as effective alternative treatments, considering the rising cost of antidepressant and anti-anxiety drugs and the high risk of side effects. Depression and anxiety disorders are among the most common mental illnesses in the world's population, characterised by low mood, poor general interest, and cognitive or motor dysfunction. Thus, this study analysed published literature on anxiety, depression, and probiotic supplementation from PubMed and Scopus, focusing on the last twenty years. This study focused on the effect of probiotics on mental health as they have drawn more attention because of their extensive clinical applications and positive impact on various diseases. Numerous studies have demonstrated how the gut microbiota might be critical for mood regulation and how probiotics can affect host health by regulating the gut-brain axis. By comparing the different works analysed, it was possible to identify a strategy by which they are selected and employed and, at the same time, to assess how the effect of probiotics can be optimised using postbiotics, an innovation to improve mental well-being in humans.
KW - Bifidobacteria
KW - Lactobacilli
KW - Mood disorders
KW - Postbiotics
KW - Probiotic supplementation
UR - http://www.scopus.com/inward/record.url?scp=85189148193&partnerID=8YFLogxK
U2 - 10.1016/j.jtcme.2024.03.011
DO - 10.1016/j.jtcme.2024.03.011
M3 - Review article
SN - 2225-4110
VL - 14
SP - 237
EP - 255
JO - Journal of Traditional and Complementary Medicine
JF - Journal of Traditional and Complementary Medicine
IS - 3
ER -