The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset

Marco Fornaro; Vincenzo Venerito; Maria Rosa Pellico; Florenzo Iannone; Mrudula Joshi; Yi-Ming Chen; Ai Lyn Tan; Sreoshy Saha; Tulika Chatterjee; Vishwesh Agarwal; Samuel Katsuyuki Shinjo; Leonardo Santos Hoff; Esha Kadam; Nelly Ziade; Tsvetelina Velikova; A T M Tanveer Hasan; Russka Shumnalieva; Marcin Milchert; Chou Luan Tan; Abraham Edgar Gracia-Ramos; Lorenzo Cavagna; Binit Vaidya; Masataka Kuwana; Syahrul Sazliyana Shaharir; Johannes Knitza; Ashima Makol; Erick Adrian Zamora Tehozol; Jorge Rojas Serrano; Hussein Halabi; Dzifa Dey; Carlos Enrique Toro-Gutiérrez; Phonpen Akarawatcharangura Goo; Carlo V Caballero-Uribe; Oliver Distler; Wanruchada Katchamart; Jessica Day; Ioannis Parodis; Elena Nikiphorou; Hector Chinoy; Vikas Agarwal; Latika Gupta; null null; Parikshit Sen; Mahnoor Javaid; Laura Andreoli; Daniele Lini; Karen Schreiber; Arvind Nune; Ai Lyn Tan; Aarat Patel; John D Pauling; Chris Wincup; Bhupen Barman; Ignacio García-De La Torre; Iris J Colunga-Pedraza; Javier Merayo-Chalico; Okwara Celestine Chibuzo; Lina El Kibbi; James B Lilleker; Babur Salim; Tamer Gheita; Miguel A Saavedra; Zoltán Griger; Sinan Kardes; Melinda Nagy Vince; Yogesh Preet Singh; Rajiv Ranjan; Avinash Jain; Sapan C Pandya; Rakesh Kumar Pilania; Aman Sharma; M Manesh Manoj; Vikas Gupta; Chengappa G Kavadichanda; Pradeepta Sekhar Patro; Sajal Ajmani; Sanat Phatak; Rudra Prosad Goswami; Abhra Chandra Chowdhury; Ashish Jacob Mathew; Padnamabha Shenoy; Ajay Asranna; Keerthi Talari Bommakanti; Anuj Shukla; Arunkumar R Pande; Kunal Chandwar; Akanksha Ghodke; Hiya Boro; Zoha Zahid Fazal; Binit Vaidya; Döndü Üsküdar Cansu; Reşit Yıldırım; Armen Yuri Gasparyan; Nicoletta Del Papa; Gianluca Sambataro; Atzeni Fabiola; Marcello Govoni; Simone Parisi; Elena Bartoloni Bocci; Gian Domenico Sebastiani; Enrico Fusaro; Marco Sebastiani; Luca Quartuccio; Franco Franceschini; Pier Paolo SAINAGHI; Giovanni Orsolini; Rossella De Angelis; Maria Giovanna Danieli; Silvia Grignaschi; Alessandro Giollo; Alessia Alunno; Lisa S Traboco; Suryo Anggoro Kusumo Wibowo; Jesús Loarce-Martos; Sergio Prieto-González; Raquel Aranega Gonzalez; Akira Yoshida; Ran Nakashima; Shinji Sato; Naoki Kimura; Yuko Kaneko; Takahisa Gono; Stylianos Tomaras; Fabian Nikolai Proft; Marie-Therese Holzer; Margarita Aleksandrovna Gromova; Or Aharonov; Zoltán Griger; Ihsane Hmamouchi; Imane El bouchti; Zineb Baba; Margherita Giannini; François Maurier; Julien Campagne; Alain Meyer; Daman Langguth; Vidya Limaye; Merrilee Needham; Nilesh Srivastav; Marie Hudson; Océane Landon-Cardinal; Wilmer Gerardo Rojas Zuleta; Álvaro Arbeláez; Javier Cajas; José António Pereira Silva; João Eurico Fonseca; Olena Zimba; Uyi Ima-Edomwonyi; Ibukunoluwa Dedeke; Emorinken Airenakho; Nwankwo Henry Madu; Abubakar Yerima; Hakeem Olaosebikan; A Becky; Oruma Devi Koussougbo; Elisa Palalane; Ho So; Manuel Francisco Ugarte-Gil; Lyn Chinchay; José Proaño Bernaola; Victorio Pimentel; Hanan Mohammed Fathi; Reem Hamdy A Mohammed; Ghita Harifi; Yurilís Fuentes-Silva; Karoll Cabriza; Jonathan Losanto; Nelly Colaman; Antonio Cachafeiro-Vilar; Generoso Guerra Bautista; Enrique Julio Giraldo Ho; Raúl González; Lilith Stange Nunez; M Cristian Vergara; Jossiell Then Báez; Hugo Alonzo; Carlos Benito Santiago Pastelin; Rodrigo García Salinas; Alejandro Quiñónez Obiols; Nilmo Chávez; Andrea Bran Ordóñez; Sandra Argueta; Gil Alberto Reyes Llerena; Radames Sierra-Zorita; Dina Arrieta; Eduardo Romero Hidalgo; Ricardo Saenz; M Idania Escalante; Roberto Morales; Wendy Calapaqui; Ivonne Quezada; Gabriela Arredondo

doi:10.1093/rheumatology/keae520

The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset

Marco Fornaro, Vincenzo Venerito, Maria Rosa Pellico, Florenzo Iannone, Mrudula Joshi, Yi-Ming Chen, Ai Lyn Tan, Sreoshy Saha, Tulika Chatterjee, Vishwesh Agarwal, Samuel Katsuyuki Shinjo, Leonardo Santos Hoff, Esha Kadam, Nelly Ziade, Tsvetelina Velikova, A T M Tanveer Hasan, Russka Shumnalieva, Marcin Milchert, Chou Luan Tan, Abraham Edgar Gracia-RamosLorenzo Cavagna, Binit Vaidya, Masataka Kuwana, Syahrul Sazliyana Shaharir, Johannes Knitza, Ashima Makol, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Hussein Halabi, Dzifa Dey, Carlos Enrique Toro-Gutiérrez, Phonpen Akarawatcharangura Goo, Carlo V Caballero-Uribe, Oliver Distler, Wanruchada Katchamart, Jessica Day, Ioannis Parodis, Elena Nikiphorou, Hector Chinoy, Vikas Agarwal, Latika Gupta, null null, Parikshit Sen, Mahnoor Javaid, Laura Andreoli, Daniele Lini, Karen Schreiber, Arvind Nune, Ai Lyn Tan, Aarat Patel, John D Pauling, Chris Wincup, Bhupen Barman, Ignacio García-De La Torre, Iris J Colunga-Pedraza, Javier Merayo-Chalico, Okwara Celestine Chibuzo, Lina El Kibbi, James B Lilleker, Babur Salim, Tamer Gheita, Miguel A Saavedra, Zoltán Griger, Sinan Kardes, Melinda Nagy Vince, Yogesh Preet Singh, Rajiv Ranjan, Avinash Jain, Sapan C Pandya, Rakesh Kumar Pilania, Aman Sharma, M Manesh Manoj, Vikas Gupta, Chengappa G Kavadichanda, Pradeepta Sekhar Patro, Sajal Ajmani, Sanat Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha Shenoy, Ajay Asranna, Keerthi Talari Bommakanti, Anuj Shukla, Arunkumar R Pande, Kunal Chandwar, Akanksha Ghodke, Hiya Boro, Zoha Zahid Fazal, Binit Vaidya, Döndü Üsküdar Cansu, Reşit Yıldırım, Armen Yuri Gasparyan, Nicoletta Del Papa, Gianluca Sambataro, Atzeni Fabiola, Marcello Govoni, Simone Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico Fusaro, Marco Sebastiani, Luca Quartuccio, Franco Franceschini, Pier Paolo SAINAGHI, Giovanni Orsolini, Rossella De Angelis, Maria Giovanna Danieli, Silvia Grignaschi, Alessandro Giollo, Alessia Alunno, Lisa S Traboco, Suryo Anggoro Kusumo Wibowo, Jesús Loarce-Martos, Sergio Prieto-González, Raquel Aranega Gonzalez, Akira Yoshida, Ran Nakashima, Shinji Sato, Naoki Kimura, Yuko Kaneko, Takahisa Gono, Stylianos Tomaras, Fabian Nikolai Proft, Marie-Therese Holzer, Margarita Aleksandrovna Gromova, Or Aharonov, Zoltán Griger, Ihsane Hmamouchi, Imane El bouchti, Zineb Baba, Margherita Giannini, François Maurier, Julien Campagne, Alain Meyer, Daman Langguth, Vidya Limaye, Merrilee Needham, Nilesh Srivastav, Marie Hudson, Océane Landon-Cardinal, Wilmer Gerardo Rojas Zuleta, Álvaro Arbeláez, Javier Cajas, José António Pereira Silva, João Eurico Fonseca, Olena Zimba, Uyi Ima-Edomwonyi, Ibukunoluwa Dedeke, Emorinken Airenakho, Nwankwo Henry Madu, Abubakar Yerima, Hakeem Olaosebikan, A Becky, Oruma Devi Koussougbo, Elisa Palalane, Ho So, Manuel Francisco Ugarte-Gil, Lyn Chinchay, José Proaño Bernaola, Victorio Pimentel, Hanan Mohammed Fathi, Reem Hamdy A Mohammed, Ghita Harifi, Yurilís Fuentes-Silva, Karoll Cabriza, Jonathan Losanto, Nelly Colaman, Antonio Cachafeiro-Vilar, Generoso Guerra Bautista, Enrique Julio Giraldo Ho, Raúl González, Lilith Stange Nunez, M Cristian Vergara, Jossiell Then Báez, Hugo Alonzo, Carlos Benito Santiago Pastelin, Rodrigo García Salinas, Alejandro Quiñónez Obiols, Nilmo Chávez, Andrea Bran Ordóñez, Sandra Argueta, Gil Alberto Reyes Llerena, Radames Sierra-Zorita, Dina Arrieta, Eduardo Romero Hidalgo, Ricardo Saenz, M Idania Escalante, Roberto Morales, Wendy Calapaqui, Ivonne Quezada, Gabriela Arredondo

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Objective: The presence of comorbidities can substantially affect patients’ quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited. Methods: We examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs) and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined basic multimorbidity (BM) as the presence of ≥2 non-rheumatic chronic conditions and complex multimorbidity (CM) as the presence of ≥3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical clustering on principal components was performed for grouping. Results: Among the COVAD respondents, 1558 IIMs, 4591 oAIRDs and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (odds ratio [OR]: 1.62 vs oAIRDs and 2.95 vs HCs, P<0.01), BM (OR: 1.66 vs oAIRDs and 3.52 vs HCs, P<0.01), CM (OR: 1.69 vs AIRDs and 6.23 vs HCs, P<0.01) and mental health disorders (MHDs) (OR: 1.33 vs oAIRDs and 2.63 vs HCs, P<0.01). Among the IIM patients, those with comorbidities or MHDs had lower PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), and PROMIS Physical Function (SF10) scores, and higher fatigue (F4a) scores (all P<0.001). PGP, PGM, SF10a and F4a were influenced by age, active disease, BM and MHDs. Four distinct clusters were identified among the IIMs according to comorbidities and PROMIS scores. Conclusion: Patients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.

Lingua originale	Inglese
pagine (da-a)	2133-2142
Numero di pagine	10
Rivista	Rheumatology
Volume	64
Numero di pubblicazione	4
DOI	https://doi.org/10.1093/rheumatology/keae520
Stato di pubblicazione	Pubblicato - 2025

Keywords

autoinflammatory condition
comorbidity
myositis
observational studies
quality of life

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Accesso al documento

10.1093/rheumatology/keae520

https://hdl.handle.net/11579/208062

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Cita questo

Fornaro, M., Venerito, V., Pellico, M. R., Iannone, F., Joshi, M., Chen, Y.-M., Tan, A. L., Saha, S., Chatterjee, T., Agarwal, V., Shinjo, S. K., Hoff, L. S., Kadam, E., Ziade, N., Velikova, T., Hasan, A. T. M. T., Shumnalieva, R., Milchert, M., Tan, C. L., ... Arredondo, G. (2025). The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset. Rheumatology, 64(4), 2133-2142. https://doi.org/10.1093/rheumatology/keae520

@article{3fd2b62d074940a29734504f618e1991,

title = "The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset",

abstract = "Objective: The presence of comorbidities can substantially affect patients{\textquoteright} quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited. Methods: We examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs) and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined basic multimorbidity (BM) as the presence of ≥2 non-rheumatic chronic conditions and complex multimorbidity (CM) as the presence of ≥3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical clustering on principal components was performed for grouping. Results: Among the COVAD respondents, 1558 IIMs, 4591 oAIRDs and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (odds ratio [OR]: 1.62 vs oAIRDs and 2.95 vs HCs, P<0.01), BM (OR: 1.66 vs oAIRDs and 3.52 vs HCs, P<0.01), CM (OR: 1.69 vs AIRDs and 6.23 vs HCs, P<0.01) and mental health disorders (MHDs) (OR: 1.33 vs oAIRDs and 2.63 vs HCs, P<0.01). Among the IIM patients, those with comorbidities or MHDs had lower PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), and PROMIS Physical Function (SF10) scores, and higher fatigue (F4a) scores (all P<0.001). PGP, PGM, SF10a and F4a were influenced by age, active disease, BM and MHDs. Four distinct clusters were identified among the IIMs according to comorbidities and PROMIS scores. Conclusion: Patients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.",

keywords = "autoinflammatory condition, comorbidity, myositis, observational studies, quality of life, autoinflammatory condition, comorbidity, myositis, observational studies, quality of life",

author = "Marco Fornaro and Vincenzo Venerito and Pellico, {Maria Rosa} and Florenzo Iannone and Mrudula Joshi and Yi-Ming Chen and Tan, {Ai Lyn} and Sreoshy Saha and Tulika Chatterjee and Vishwesh Agarwal and Shinjo, {Samuel Katsuyuki} and Hoff, {Leonardo Santos} and Esha Kadam and Nelly Ziade and Tsvetelina Velikova and Hasan, {A T M Tanveer} and Russka Shumnalieva and Marcin Milchert and Tan, {Chou Luan} and Gracia-Ramos, {Abraham Edgar} and Lorenzo Cavagna and Binit Vaidya and Masataka Kuwana and Shaharir, {Syahrul Sazliyana} and Johannes Knitza and Ashima Makol and Tehozol, {Erick Adrian Zamora} and Serrano, {Jorge Rojas} and Hussein Halabi and Dzifa Dey and Toro-Guti{\'e}rrez, {Carlos Enrique} and Goo, {Phonpen Akarawatcharangura} and Caballero-Uribe, {Carlo V} and Oliver Distler and Wanruchada Katchamart and Jessica Day and Ioannis Parodis and Elena Nikiphorou and Hector Chinoy and Vikas Agarwal and Latika Gupta and null null and Parikshit Sen and Mahnoor Javaid and Laura Andreoli and Daniele Lini and Karen Schreiber and Arvind Nune and Tan, {Ai Lyn} and Aarat Patel and Pauling, {John D} and Chris Wincup and Bhupen Barman and {Garc{\'i}a-De La Torre}, Ignacio and Colunga-Pedraza, {Iris J} and Javier Merayo-Chalico and Chibuzo, {Okwara Celestine} and {El Kibbi}, Lina and Lilleker, {James B} and Babur Salim and Tamer Gheita and Saavedra, {Miguel A} and Zolt{\'a}n Griger and Sinan Kardes and Vince, {Melinda Nagy} and Singh, {Yogesh Preet} and Rajiv Ranjan and Avinash Jain and Pandya, {Sapan C} and Pilania, {Rakesh Kumar} and Aman Sharma and {Manesh Manoj}, M and Vikas Gupta and Kavadichanda, {Chengappa G} and Patro, {Pradeepta Sekhar} and Sajal Ajmani and Sanat Phatak and Goswami, {Rudra Prosad} and Chowdhury, {Abhra Chandra} and Mathew, {Ashish Jacob} and Padnamabha Shenoy and Ajay Asranna and Bommakanti, {Keerthi Talari} and Anuj Shukla and Pande, {Arunkumar R} and Kunal Chandwar and Akanksha Ghodke and Hiya Boro and Fazal, {Zoha Zahid} and Binit Vaidya and Cansu, {D{\"o}nd{\"u} {\"U}sk{\"u}dar} and Re{\c s}it Yıldırım and Gasparyan, {Armen Yuri} and {Del Papa}, Nicoletta and Gianluca Sambataro and Atzeni Fabiola and Marcello Govoni and Simone Parisi and Bocci, {Elena Bartoloni} and Sebastiani, {Gian Domenico} and Enrico Fusaro and Marco Sebastiani and Luca Quartuccio and Franco Franceschini and SAINAGHI, {Pier Paolo} and Giovanni Orsolini and {De Angelis}, Rossella and Danieli, {Maria Giovanna} and Silvia Grignaschi and Alessandro Giollo and Alessia Alunno and Traboco, {Lisa S} and Wibowo, {Suryo Anggoro Kusumo} and Jes{\'u}s Loarce-Martos and Sergio Prieto-Gonz{\'a}lez and Gonzalez, {Raquel Aranega} and Akira Yoshida and Ran Nakashima and Shinji Sato and Naoki Kimura and Yuko Kaneko and Takahisa Gono and Stylianos Tomaras and Proft, {Fabian Nikolai} and Marie-Therese Holzer and Gromova, {Margarita Aleksandrovna} and Or Aharonov and Zolt{\'a}n Griger and Ihsane Hmamouchi and {El bouchti}, Imane and Zineb Baba and Margherita Giannini and Fran{\c c}ois Maurier and Julien Campagne and Alain Meyer and Daman Langguth and Vidya Limaye and Merrilee Needham and Nilesh Srivastav and Marie Hudson and Oc{\'e}ane Landon-Cardinal and Zuleta, {Wilmer Gerardo Rojas} and {\'A}lvaro Arbel{\'a}ez and Javier Cajas and Silva, {Jos{\'e} Ant{\'o}nio Pereira} and Fonseca, {Jo{\~a}o Eurico} and Olena Zimba and Uyi Ima-Edomwonyi and Ibukunoluwa Dedeke and Emorinken Airenakho and Madu, {Nwankwo Henry} and Abubakar Yerima and Hakeem Olaosebikan and A Becky and Koussougbo, {Oruma Devi} and Elisa Palalane and Ho So and Ugarte-Gil, {Manuel Francisco} and Lyn Chinchay and Bernaola, {Jos{\'e} Proa{\~n}o} and Victorio Pimentel and Fathi, {Hanan Mohammed} and Mohammed, {Reem Hamdy A} and Ghita Harifi and Yuril{\'i}s Fuentes-Silva and Karoll Cabriza and Jonathan Losanto and Nelly Colaman and Antonio Cachafeiro-Vilar and Bautista, {Generoso Guerra} and Ho, {Enrique Julio Giraldo} and Ra{\'u}l Gonz{\'a}lez and Nunez, {Lilith Stange} and {Cristian Vergara}, M and B{\'a}ez, {Jossiell Then} and Hugo Alonzo and Pastelin, {Carlos Benito Santiago} and Salinas, {Rodrigo Garc{\'i}a} and Obiols, {Alejandro Qui{\~n}{\'o}nez} and Nilmo Ch{\'a}vez and Ord{\'o}{\~n}ez, {Andrea Bran} and Sandra Argueta and Llerena, {Gil Alberto Reyes} and Radames Sierra-Zorita and Dina Arrieta and Hidalgo, {Eduardo Romero} and Ricardo Saenz and {Idania Escalante}, M and Roberto Morales and Wendy Calapaqui and Ivonne Quezada and Gabriela Arredondo",

year = "2025",

doi = "10.1093/rheumatology/keae520",

language = "English",

volume = "64",

pages = "2133--2142",

journal = "Rheumatology",

issn = "1462-0324",

publisher = "Oxford University Press",

number = "4",

}

Fornaro, M, Venerito, V, Pellico, MR, Iannone, F, Joshi, M, Chen, Y-M, Tan, AL, Saha, S, Chatterjee, T, Agarwal, V, Shinjo, SK, Hoff, LS, Kadam, E, Ziade, N, Velikova, T, Hasan, ATMT, Shumnalieva, R, Milchert, M, Tan, CL, Gracia-Ramos, AE, Cavagna, L, Vaidya, B, Kuwana, M, Shaharir, SS, Knitza, J, Makol, A, Tehozol, EAZ, Serrano, JR, Halabi, H, Dey, D, Toro-Gutiérrez, CE, Goo, PA, Caballero-Uribe, CV, Distler, O, Katchamart, W, Day, J, Parodis, I, Nikiphorou, E, Chinoy, H, Agarwal, V, Gupta, L, null, N, Sen, P, Javaid, M, Andreoli, L, Lini, D, Schreiber, K, Nune, A, Tan, AL, Patel, A, Pauling, JD, Wincup, C, Barman, B, García-De La Torre, I, Colunga-Pedraza, IJ, Merayo-Chalico, J, Chibuzo, OC, El Kibbi, L, Lilleker, JB, Salim, B, Gheita, T, Saavedra, MA, Griger, Z, Kardes, S, Vince, MN, Singh, YP, Ranjan, R, Jain, A, Pandya, SC, Pilania, RK, Sharma, A, Manesh Manoj, M, Gupta, V, Kavadichanda, CG, Patro, PS, Ajmani, S, Phatak, S, Goswami, RP, Chowdhury, AC, Mathew, AJ, Shenoy, P, Asranna, A, Bommakanti, KT, Shukla, A, Pande, AR, Chandwar, K, Ghodke, A, Boro, H, Fazal, ZZ, Vaidya, B, Cansu, DÜ, Yıldırım, R, Gasparyan, AY, Del Papa, N, Sambataro, G, Fabiola, A, Govoni, M, Parisi, S, Bocci, EB, Sebastiani, GD, Fusaro, E, Sebastiani, M, Quartuccio, L, Franceschini, F, SAINAGHI, PP, Orsolini, G, De Angelis, R, Danieli, MG, Grignaschi, S, Giollo, A, Alunno, A, Traboco, LS, Wibowo, SAK, Loarce-Martos, J, Prieto-González, S, Gonzalez, RA, Yoshida, A, Nakashima, R, Sato, S, Kimura, N, Kaneko, Y, Gono, T, Tomaras, S, Proft, FN, Holzer, M-T, Gromova, MA, Aharonov, O, Griger, Z, Hmamouchi, I, El bouchti, I, Baba, Z, Giannini, M, Maurier, F, Campagne, J, Meyer, A, Langguth, D, Limaye, V, Needham, M, Srivastav, N, Hudson, M, Landon-Cardinal, O, Zuleta, WGR, Arbeláez, Á, Cajas, J, Silva, JAP, Fonseca, JE, Zimba, O, Ima-Edomwonyi, U, Dedeke, I, Airenakho, E, Madu, NH, Yerima, A, Olaosebikan, H, Becky, A, Koussougbo, OD, Palalane, E, So, H, Ugarte-Gil, MF, Chinchay, L, Bernaola, JP, Pimentel, V, Fathi, HM, Mohammed, RHA, Harifi, G, Fuentes-Silva, Y, Cabriza, K, Losanto, J, Colaman, N, Cachafeiro-Vilar, A, Bautista, GG, Ho, EJG, González, R, Nunez, LS, Cristian Vergara, M, Báez, JT, Alonzo, H, Pastelin, CBS, Salinas, RG, Obiols, AQ, Chávez, N, Ordóñez, AB, Argueta, S, Llerena, GAR, Sierra-Zorita, R, Arrieta, D, Hidalgo, ER, Saenz, R, Idania Escalante, M, Morales, R, Calapaqui, W, Quezada, I & Arredondo, G 2025, 'The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset', Rheumatology, vol. 64, n. 4, pagg. 2133-2142. https://doi.org/10.1093/rheumatology/keae520

TY - JOUR

T1 - The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset

AU - Fornaro, Marco

AU - Venerito, Vincenzo

AU - Pellico, Maria Rosa

AU - Iannone, Florenzo

AU - Joshi, Mrudula

AU - Chen, Yi-Ming

AU - Tan, Ai Lyn

AU - Saha, Sreoshy

AU - Chatterjee, Tulika

AU - Agarwal, Vishwesh

AU - Shinjo, Samuel Katsuyuki

AU - Hoff, Leonardo Santos

AU - Kadam, Esha

AU - Ziade, Nelly

AU - Velikova, Tsvetelina

AU - Hasan, A T M Tanveer

AU - Shumnalieva, Russka

AU - Milchert, Marcin

AU - Tan, Chou Luan

AU - Gracia-Ramos, Abraham Edgar

AU - Cavagna, Lorenzo

AU - Vaidya, Binit

AU - Kuwana, Masataka

AU - Shaharir, Syahrul Sazliyana

AU - Knitza, Johannes

AU - Makol, Ashima

AU - Tehozol, Erick Adrian Zamora

AU - Serrano, Jorge Rojas

AU - Halabi, Hussein

AU - Dey, Dzifa

AU - Toro-Gutiérrez, Carlos Enrique

AU - Goo, Phonpen Akarawatcharangura

AU - Caballero-Uribe, Carlo V

AU - Distler, Oliver

AU - Katchamart, Wanruchada

AU - Day, Jessica

AU - Parodis, Ioannis

AU - Nikiphorou, Elena

AU - Chinoy, Hector

AU - Agarwal, Vikas

AU - Gupta, Latika

AU - null, null

AU - Sen, Parikshit

AU - Javaid, Mahnoor

AU - Andreoli, Laura

AU - Lini, Daniele

AU - Schreiber, Karen

AU - Nune, Arvind

AU - Tan, Ai Lyn

AU - Patel, Aarat

AU - Pauling, John D

AU - Wincup, Chris

AU - Barman, Bhupen

AU - García-De La Torre, Ignacio

AU - Colunga-Pedraza, Iris J

AU - Merayo-Chalico, Javier

AU - Chibuzo, Okwara Celestine

AU - El Kibbi, Lina

AU - Lilleker, James B

AU - Salim, Babur

AU - Gheita, Tamer

AU - Saavedra, Miguel A

AU - Griger, Zoltán

AU - Kardes, Sinan

AU - Vince, Melinda Nagy

AU - Singh, Yogesh Preet

AU - Ranjan, Rajiv

AU - Jain, Avinash

AU - Pandya, Sapan C

AU - Pilania, Rakesh Kumar

AU - Sharma, Aman

AU - Manesh Manoj, M

AU - Gupta, Vikas

AU - Kavadichanda, Chengappa G

AU - Patro, Pradeepta Sekhar

AU - Ajmani, Sajal

AU - Phatak, Sanat

AU - Goswami, Rudra Prosad

AU - Chowdhury, Abhra Chandra

AU - Mathew, Ashish Jacob

AU - Shenoy, Padnamabha

AU - Asranna, Ajay

AU - Bommakanti, Keerthi Talari

AU - Shukla, Anuj

AU - Pande, Arunkumar R

AU - Chandwar, Kunal

AU - Ghodke, Akanksha

AU - Boro, Hiya

AU - Fazal, Zoha Zahid

AU - Vaidya, Binit

AU - Cansu, Döndü Üsküdar

AU - Yıldırım, Reşit

AU - Gasparyan, Armen Yuri

AU - Del Papa, Nicoletta

AU - Sambataro, Gianluca

AU - Fabiola, Atzeni

AU - Govoni, Marcello

AU - Parisi, Simone

AU - Bocci, Elena Bartoloni

AU - Sebastiani, Gian Domenico

AU - Fusaro, Enrico

AU - Sebastiani, Marco

AU - Quartuccio, Luca

AU - Franceschini, Franco

AU - SAINAGHI, Pier Paolo

AU - Orsolini, Giovanni

AU - De Angelis, Rossella

AU - Danieli, Maria Giovanna

AU - Grignaschi, Silvia

AU - Giollo, Alessandro

AU - Alunno, Alessia

AU - Traboco, Lisa S

AU - Wibowo, Suryo Anggoro Kusumo

AU - Loarce-Martos, Jesús

AU - Prieto-González, Sergio

AU - Gonzalez, Raquel Aranega

AU - Yoshida, Akira

AU - Nakashima, Ran

AU - Sato, Shinji

AU - Kimura, Naoki

AU - Kaneko, Yuko

AU - Gono, Takahisa

AU - Tomaras, Stylianos

AU - Proft, Fabian Nikolai

AU - Holzer, Marie-Therese

AU - Gromova, Margarita Aleksandrovna

AU - Aharonov, Or

AU - Griger, Zoltán

AU - Hmamouchi, Ihsane

AU - El bouchti, Imane

AU - Baba, Zineb

AU - Giannini, Margherita

AU - Maurier, François

AU - Campagne, Julien

AU - Meyer, Alain

AU - Langguth, Daman

AU - Limaye, Vidya

AU - Needham, Merrilee

AU - Srivastav, Nilesh

AU - Hudson, Marie

AU - Landon-Cardinal, Océane

AU - Zuleta, Wilmer Gerardo Rojas

AU - Arbeláez, Álvaro

AU - Cajas, Javier

AU - Silva, José António Pereira

AU - Fonseca, João Eurico

AU - Zimba, Olena

AU - Ima-Edomwonyi, Uyi

AU - Dedeke, Ibukunoluwa

AU - Airenakho, Emorinken

AU - Madu, Nwankwo Henry

AU - Yerima, Abubakar

AU - Olaosebikan, Hakeem

AU - Becky, A

AU - Koussougbo, Oruma Devi

AU - Palalane, Elisa

AU - So, Ho

AU - Ugarte-Gil, Manuel Francisco

AU - Chinchay, Lyn

AU - Bernaola, José Proaño

AU - Pimentel, Victorio

AU - Fathi, Hanan Mohammed

AU - Mohammed, Reem Hamdy A

AU - Harifi, Ghita

AU - Fuentes-Silva, Yurilís

AU - Cabriza, Karoll

AU - Losanto, Jonathan

AU - Colaman, Nelly

AU - Cachafeiro-Vilar, Antonio

AU - Bautista, Generoso Guerra

AU - Ho, Enrique Julio Giraldo

AU - González, Raúl

AU - Nunez, Lilith Stange

AU - Cristian Vergara, M

AU - Báez, Jossiell Then

AU - Alonzo, Hugo

AU - Pastelin, Carlos Benito Santiago

AU - Salinas, Rodrigo García

AU - Obiols, Alejandro Quiñónez

AU - Chávez, Nilmo

AU - Ordóñez, Andrea Bran

AU - Argueta, Sandra

AU - Llerena, Gil Alberto Reyes

AU - Sierra-Zorita, Radames

AU - Arrieta, Dina

AU - Hidalgo, Eduardo Romero

AU - Saenz, Ricardo

AU - Idania Escalante, M

AU - Morales, Roberto

AU - Calapaqui, Wendy

AU - Quezada, Ivonne

AU - Arredondo, Gabriela

PY - 2025

Y1 - 2025

N2 - Objective: The presence of comorbidities can substantially affect patients’ quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited. Methods: We examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs) and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined basic multimorbidity (BM) as the presence of ≥2 non-rheumatic chronic conditions and complex multimorbidity (CM) as the presence of ≥3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical clustering on principal components was performed for grouping. Results: Among the COVAD respondents, 1558 IIMs, 4591 oAIRDs and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (odds ratio [OR]: 1.62 vs oAIRDs and 2.95 vs HCs, P<0.01), BM (OR: 1.66 vs oAIRDs and 3.52 vs HCs, P<0.01), CM (OR: 1.69 vs AIRDs and 6.23 vs HCs, P<0.01) and mental health disorders (MHDs) (OR: 1.33 vs oAIRDs and 2.63 vs HCs, P<0.01). Among the IIM patients, those with comorbidities or MHDs had lower PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), and PROMIS Physical Function (SF10) scores, and higher fatigue (F4a) scores (all P<0.001). PGP, PGM, SF10a and F4a were influenced by age, active disease, BM and MHDs. Four distinct clusters were identified among the IIMs according to comorbidities and PROMIS scores. Conclusion: Patients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.

AB - Objective: The presence of comorbidities can substantially affect patients’ quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited. Methods: We examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs) and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined basic multimorbidity (BM) as the presence of ≥2 non-rheumatic chronic conditions and complex multimorbidity (CM) as the presence of ≥3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical clustering on principal components was performed for grouping. Results: Among the COVAD respondents, 1558 IIMs, 4591 oAIRDs and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (odds ratio [OR]: 1.62 vs oAIRDs and 2.95 vs HCs, P<0.01), BM (OR: 1.66 vs oAIRDs and 3.52 vs HCs, P<0.01), CM (OR: 1.69 vs AIRDs and 6.23 vs HCs, P<0.01) and mental health disorders (MHDs) (OR: 1.33 vs oAIRDs and 2.63 vs HCs, P<0.01). Among the IIM patients, those with comorbidities or MHDs had lower PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), and PROMIS Physical Function (SF10) scores, and higher fatigue (F4a) scores (all P<0.001). PGP, PGM, SF10a and F4a were influenced by age, active disease, BM and MHDs. Four distinct clusters were identified among the IIMs according to comorbidities and PROMIS scores. Conclusion: Patients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.

KW - autoinflammatory condition

KW - comorbidity

KW - myositis

KW - observational studies

KW - quality of life

KW - autoinflammatory condition

KW - comorbidity

KW - myositis

KW - observational studies

KW - quality of life

UR - https://iris.uniupo.it/handle/11579/208062

U2 - 10.1093/rheumatology/keae520

DO - 10.1093/rheumatology/keae520

M3 - Article

SN - 1462-0324

VL - 64

SP - 2133

EP - 2142

JO - Rheumatology

JF - Rheumatology

IS - 4

ER -

The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset

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