The IL12B gene does not confer susceptibility to coeliac disease

A. S. Louka; Å Torinsson Naluai; S. D'Alfonso; H. Ascher; I. Coto; J. Ek; M. Giordano; A. H. Gudjónsdóttir; M. Mellai; P. Momigliano-Richiardi; S. Percopo; L. Samuelsson; J. Wahlström; L. Greco; L. M. Sollid

doi:10.1034/j.1399-0039.2002.590117.x

The IL12B gene does not confer susceptibility to coeliac disease

A. S. Louka, Å Torinsson Naluai, S. D'Alfonso, H. Ascher, I. Coto, J. Ek, M. Giordano, A. H. Gudjónsdóttir, M. Mellai, P. Momigliano-Richiardi, S. Percopo, L. Samuelsson, J. Wahlström, L. Greco, L. M. Sollid

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Coeliac disease (CD) is a chronic inflammatory disorder where dietary gluten is not tolerated. In the lesion there are gluten reactive T cells predominantly secreting γ-interferon. Both HLA and non-HLA genes contribute to CD susceptibility. Interleukin-12 (IL-12) regulates γ-interferon production. The IL12B gene is located in a region (5q31.1-33.1) where there is evidence for linkage with CD. Allele 1 of an IL12B 3′UTR single-nucleotide polymorphism leads to increased expression of IL-12, and was recently implicated in susceptibility for type 1 diabetes (T1D). We found no evidence for association of allele 1 to CD by the transmission/disequilibrium test or case-control approach. No increased frequency was observed in patients belonging to families where the disease was linked to markers on chromosome 5q. Unlike T1D, allele 1 does not appear to confer susceptibility to CD.

Lingua originale	Inglese
pagine (da-a)	70-72
Numero di pagine	3
Rivista	Tissue Antigens
Volume	59
Numero di pubblicazione	1
DOI	https://doi.org/10.1034/j.1399-0039.2002.590117.x
Stato di pubblicazione	Pubblicato - 2002
Pubblicato esternamente	Sì

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Louka, A. S., Torinsson Naluai, Å., D'Alfonso, S., Ascher, H., Coto, I., Ek, J., Giordano, M., Gudjónsdóttir, A. H., Mellai, M., Momigliano-Richiardi, P., Percopo, S., Samuelsson, L., Wahlström, J., Greco, L., & Sollid, L. M. (2002). The IL12B gene does not confer susceptibility to coeliac disease. Tissue Antigens, 59(1), 70-72. https://doi.org/10.1034/j.1399-0039.2002.590117.x

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title = "The IL12B gene does not confer susceptibility to coeliac disease",

abstract = "Coeliac disease (CD) is a chronic inflammatory disorder where dietary gluten is not tolerated. In the lesion there are gluten reactive T cells predominantly secreting γ-interferon. Both HLA and non-HLA genes contribute to CD susceptibility. Interleukin-12 (IL-12) regulates γ-interferon production. The IL12B gene is located in a region (5q31.1-33.1) where there is evidence for linkage with CD. Allele 1 of an IL12B 3′UTR single-nucleotide polymorphism leads to increased expression of IL-12, and was recently implicated in susceptibility for type 1 diabetes (T1D). We found no evidence for association of allele 1 to CD by the transmission/disequilibrium test or case-control approach. No increased frequency was observed in patients belonging to families where the disease was linked to markers on chromosome 5q. Unlike T1D, allele 1 does not appear to confer susceptibility to CD.",

keywords = "Celiac disease, IL12B, Interleukin-12, Single-nucleotide polymorphism, TDT",

author = "Louka, {A. S.} and {Torinsson Naluai}, {\AA} and S. D'Alfonso and H. Ascher and I. Coto and J. Ek and M. Giordano and Gudj{\'o}nsd{\'o}ttir, {A. H.} and M. Mellai and P. Momigliano-Richiardi and S. Percopo and L. Samuelsson and J. Wahlstr{\"o}m and L. Greco and Sollid, {L. M.}",

year = "2002",

doi = "10.1034/j.1399-0039.2002.590117.x",

language = "English",

volume = "59",

pages = "70--72",

journal = "Tissue Antigens",

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Louka, AS, Torinsson Naluai, Å, D'Alfonso, S, Ascher, H, Coto, I, Ek, J, Giordano, M, Gudjónsdóttir, AH, Mellai, M, Momigliano-Richiardi, P, Percopo, S, Samuelsson, L, Wahlström, J, Greco, L & Sollid, LM 2002, 'The IL12B gene does not confer susceptibility to coeliac disease', Tissue Antigens, vol. 59, n. 1, pagg. 70-72. https://doi.org/10.1034/j.1399-0039.2002.590117.x

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T1 - The IL12B gene does not confer susceptibility to coeliac disease

AU - Louka, A. S.

AU - Torinsson Naluai, Å

AU - D'Alfonso, S.

AU - Ascher, H.

AU - Coto, I.

AU - Ek, J.

AU - Giordano, M.

AU - Gudjónsdóttir, A. H.

AU - Mellai, M.

AU - Momigliano-Richiardi, P.

AU - Percopo, S.

AU - Samuelsson, L.

AU - Wahlström, J.

AU - Greco, L.

AU - Sollid, L. M.

PY - 2002

Y1 - 2002

N2 - Coeliac disease (CD) is a chronic inflammatory disorder where dietary gluten is not tolerated. In the lesion there are gluten reactive T cells predominantly secreting γ-interferon. Both HLA and non-HLA genes contribute to CD susceptibility. Interleukin-12 (IL-12) regulates γ-interferon production. The IL12B gene is located in a region (5q31.1-33.1) where there is evidence for linkage with CD. Allele 1 of an IL12B 3′UTR single-nucleotide polymorphism leads to increased expression of IL-12, and was recently implicated in susceptibility for type 1 diabetes (T1D). We found no evidence for association of allele 1 to CD by the transmission/disequilibrium test or case-control approach. No increased frequency was observed in patients belonging to families where the disease was linked to markers on chromosome 5q. Unlike T1D, allele 1 does not appear to confer susceptibility to CD.

AB - Coeliac disease (CD) is a chronic inflammatory disorder where dietary gluten is not tolerated. In the lesion there are gluten reactive T cells predominantly secreting γ-interferon. Both HLA and non-HLA genes contribute to CD susceptibility. Interleukin-12 (IL-12) regulates γ-interferon production. The IL12B gene is located in a region (5q31.1-33.1) where there is evidence for linkage with CD. Allele 1 of an IL12B 3′UTR single-nucleotide polymorphism leads to increased expression of IL-12, and was recently implicated in susceptibility for type 1 diabetes (T1D). We found no evidence for association of allele 1 to CD by the transmission/disequilibrium test or case-control approach. No increased frequency was observed in patients belonging to families where the disease was linked to markers on chromosome 5q. Unlike T1D, allele 1 does not appear to confer susceptibility to CD.

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KW - IL12B

KW - Interleukin-12

KW - Single-nucleotide polymorphism

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U2 - 10.1034/j.1399-0039.2002.590117.x

DO - 10.1034/j.1399-0039.2002.590117.x

M3 - Article

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VL - 59

SP - 70

EP - 72

JO - Tissue Antigens

JF - Tissue Antigens

IS - 1

ER -

The IL12B gene does not confer susceptibility to coeliac disease

Abstract

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