The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process

Flavio Moroni; Grazia Lombardi; Gloriano Moneti; Caterina Aldinio

doi:10.1016/0304-3940(84)90385-9

The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process

Flavio Moroni, Grazia Lombardi, Gloriano Moneti, Caterina Aldinio

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The distribution of the excitotoxin quinolinic acid (QUIN) has been evaluated in the brains of rabbit, guinea pig and rat, using a mass spectrometric method. Furthermore, the cortical content of this molecule has been measured during the development and the aging of the rat. The cortex contained the highest concentration of QUIN in the three species studied. During the rat development the concentration of this molecule increased and unusually high amounts of it were found in approximately 50% of 30-month-old rats.

Lingua originale	Inglese
pagine (da-a)	51-55
Numero di pagine	5
Rivista	Neuroscience Letters
Volume	47
Numero di pubblicazione	1
DOI	https://doi.org/10.1016/0304-3940(84)90385-9
Stato di pubblicazione	Pubblicato - 1 giu 1984
Pubblicato esternamente	Sì

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10.1016/0304-3940(84)90385-9

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title = "The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process",

abstract = "The distribution of the excitotoxin quinolinic acid (QUIN) has been evaluated in the brains of rabbit, guinea pig and rat, using a mass spectrometric method. Furthermore, the cortical content of this molecule has been measured during the development and the aging of the rat. The cortex contained the highest concentration of QUIN in the three species studied. During the rat development the concentration of this molecule increased and unusually high amounts of it were found in approximately 50% of 30-month-old rats.",

keywords = "aging, development, excitotoxins, guinea pig, mass fragmentography, quinolinic acid, rabbit, rat, tryptophan metabolism",

author = "Flavio Moroni and Grazia Lombardi and Gloriano Moneti and Caterina Aldinio",

note = "Funding Information: This work was supported by grants from CNR and from the University of Firenze. We wish to thank G. Bucelli for his expert technical assistance and the Italian Study Group of Brain Aging for supplying the rats.",

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T1 - The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process

AU - Moroni, Flavio

AU - Lombardi, Grazia

AU - Moneti, Gloriano

AU - Aldinio, Caterina

N1 - Funding Information: This work was supported by grants from CNR and from the University of Firenze. We wish to thank G. Bucelli for his expert technical assistance and the Italian Study Group of Brain Aging for supplying the rats.

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N2 - The distribution of the excitotoxin quinolinic acid (QUIN) has been evaluated in the brains of rabbit, guinea pig and rat, using a mass spectrometric method. Furthermore, the cortical content of this molecule has been measured during the development and the aging of the rat. The cortex contained the highest concentration of QUIN in the three species studied. During the rat development the concentration of this molecule increased and unusually high amounts of it were found in approximately 50% of 30-month-old rats.

AB - The distribution of the excitotoxin quinolinic acid (QUIN) has been evaluated in the brains of rabbit, guinea pig and rat, using a mass spectrometric method. Furthermore, the cortical content of this molecule has been measured during the development and the aging of the rat. The cortex contained the highest concentration of QUIN in the three species studied. During the rat development the concentration of this molecule increased and unusually high amounts of it were found in approximately 50% of 30-month-old rats.

KW - aging

KW - development

KW - excitotoxins

KW - guinea pig

KW - mass fragmentography

KW - quinolinic acid

KW - rabbit

KW - rat

KW - tryptophan metabolism

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VL - 47

SP - 51

EP - 55

JO - Neuroscience Letters

JF - Neuroscience Letters

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The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process

Abstract

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