TY - JOUR
T1 - The effect of formulation and concentration of cholesteryl butyrate solid lipid nanospheres (SLN) on NIH-H460 cell proliferation
AU - Ugazio, Elena
AU - Marengo, Emilio
AU - Pellizzaro, Cinzia
AU - Coradini, Danila
AU - Peira, Elena
AU - Daidone, Maria Grazia
AU - Gasco, Maria Rosa
N1 - Funding Information:
The study was supported by Turin University funding (ex-60%) and by Consiglio Nazionale delle Ricerche (CNR).
PY - 2001
Y1 - 2001
N2 - Experimental factorial design was used to evaluate the influence of two factors involved in producing cholesteryl butyrate (chol-but) solid lipid nanospheres (SLN), microemulsion formulation and microemulsion/water ratio, on the effect of the SLN on the proliferation of NIH-H460, a non-small-cell lung carcinoma; six experimental settings were tested. The cells were treated with scalar concentrations of cholesteryl butyrate (from 0.008 to 1.000 mM) for each experimental condition; NIH-H460 cell growth was inhibited in all cases. The best experimental setting provided complete inhibition at 0.125 mM chol-but, while at the same concentration sodium butyrate provided only 38% inhibition.
AB - Experimental factorial design was used to evaluate the influence of two factors involved in producing cholesteryl butyrate (chol-but) solid lipid nanospheres (SLN), microemulsion formulation and microemulsion/water ratio, on the effect of the SLN on the proliferation of NIH-H460, a non-small-cell lung carcinoma; six experimental settings were tested. The cells were treated with scalar concentrations of cholesteryl butyrate (from 0.008 to 1.000 mM) for each experimental condition; NIH-H460 cell growth was inhibited in all cases. The best experimental setting provided complete inhibition at 0.125 mM chol-but, while at the same concentration sodium butyrate provided only 38% inhibition.
KW - Cholesteryl butyrate
KW - Colloidal systems
KW - Factorial design
KW - NIH-H460 cell proliferation
KW - Solid lipid nanospheres
UR - http://www.scopus.com/inward/record.url?scp=0034885601&partnerID=8YFLogxK
U2 - 10.1016/S0939-6411(01)00176-X
DO - 10.1016/S0939-6411(01)00176-X
M3 - Article
SN - 0939-6411
VL - 52
SP - 197
EP - 202
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
IS - 2
ER -