The effect of chronic atropine administration on mouse motility and on ACh levels in the central nervous system

Luigi Molinengo; Anna Fundarò; Marco Orsetti

doi:10.1016/0091-3057(89)90085-3

The effect of chronic atropine administration on mouse motility and on ACh levels in the central nervous system

Luigi Molinengo
, Anna Fundarò
, Marco Orsetti

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Changes in mouse motility and CNS cortical and subcortical ACh levels were studied after chronic (20 days) administration of 30, 40 and 60 mg/kg/day atropine. An increase in motility similar to that induced by tropine administration was observed, whereas the ACh levels reduction caused by acute administration was not repeated. These results suggest that changes in mouse motility caused by atropine are not correlated to its modification of ACh levels in the CNS.

Lingua originale	Inglese
pagine (da-a)	1075-1077
Numero di pagine	3
Rivista	Pharmacology Biochemistry and Behavior
Volume	32
Numero di pubblicazione	4
DOI	https://doi.org/10.1016/0091-3057(89)90085-3
Stato di pubblicazione	Pubblicato - apr 1989
Pubblicato esternamente	Sì

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10.1016/0091-3057(89)90085-3

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title = "The effect of chronic atropine administration on mouse motility and on ACh levels in the central nervous system",

abstract = "Changes in mouse motility and CNS cortical and subcortical ACh levels were studied after chronic (20 days) administration of 30, 40 and 60 mg/kg/day atropine. An increase in motility similar to that induced by tropine administration was observed, whereas the ACh levels reduction caused by acute administration was not repeated. These results suggest that changes in mouse motility caused by atropine are not correlated to its modification of ACh levels in the CNS.",

keywords = "ACh levels, Atropine, Chronic treatment, Mouse motility",

author = "Luigi Molinengo and Anna Fundar{\`o} and Marco Orsetti",

year = "1989",

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AU - Molinengo, Luigi

AU - Fundarò, Anna

AU - Orsetti, Marco

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N2 - Changes in mouse motility and CNS cortical and subcortical ACh levels were studied after chronic (20 days) administration of 30, 40 and 60 mg/kg/day atropine. An increase in motility similar to that induced by tropine administration was observed, whereas the ACh levels reduction caused by acute administration was not repeated. These results suggest that changes in mouse motility caused by atropine are not correlated to its modification of ACh levels in the CNS.

AB - Changes in mouse motility and CNS cortical and subcortical ACh levels were studied after chronic (20 days) administration of 30, 40 and 60 mg/kg/day atropine. An increase in motility similar to that induced by tropine administration was observed, whereas the ACh levels reduction caused by acute administration was not repeated. These results suggest that changes in mouse motility caused by atropine are not correlated to its modification of ACh levels in the CNS.

KW - ACh levels

KW - Atropine

KW - Chronic treatment

KW - Mouse motility

UR - https://www.scopus.com/pages/publications/0024403151

U2 - 10.1016/0091-3057(89)90085-3

DO - 10.1016/0091-3057(89)90085-3

M3 - Article

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ER -

The effect of chronic atropine administration on mouse motility and on ACh levels in the central nervous system

Abstract

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