TY - JOUR
T1 - The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European prospective investigation into cancer and nutrition
AU - Crowe, Francesca L.
AU - Key, Timothy J.
AU - Allen, Naomi E.
AU - Appleby, Paul N.
AU - Roddam, Andrew
AU - Overvad, Kim
AU - Grønbæk, Henning
AU - Tjønneland, Anne
AU - Halkjær, Jutte
AU - Dossus, Laure
AU - Boeing, Heiner
AU - Kröger, Janine
AU - Trichopoulou, Antonia
AU - Dilis, Vardis
AU - Trichopoulos, Dimitrios
AU - Boutron-Ruault, Marie Christine
AU - De Lauzon, Blandine
AU - Clavel-Chapelon, Françoise
AU - Palli, Domenico
AU - Berrino, Franco
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Bueno-de-Mesquita, H. Bas
AU - Vrieling, Alina
AU - Van Gils, Carla H.
AU - Peeters, Petra H.M.
AU - Gram, Inger T.
AU - Skeie, Guri
AU - Lund, Eiliv
AU - Rodríguez, Laudina
AU - Jakszyn, Paula
AU - Molina-Montes, Esther
AU - Tormo, María J.
AU - Barricarte, Aurelio
AU - Larrañaga, Nerea
AU - Khaw, Kay Tee
AU - Bingham, Sheila
AU - Rinaldi, Sabina
AU - Slimani, Nadia
AU - Norat, Teresa
AU - Gallo, Valentina
AU - Riboli, Elio
AU - Kaaks, Rudolf
PY - 2009/5
Y1 - 2009/5
N2 - Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products.
AB - Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products.
UR - http://www.scopus.com/inward/record.url?scp=66549097704&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-08-0781
DO - 10.1158/1055-9965.EPI-08-0781
M3 - Article
SN - 1055-9965
VL - 18
SP - 1333
EP - 1340
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 5
ER -
