The antianaphylactic action of histamine H2‐receptor agonists in the guinea‐pig isolated heart

P. Blandina; Sandra Brunelleschi; R. Fantozzi; Eliana Giannella; P. F. Mannaioni; Emanuela Masini

doi:10.1111/j.1476-5381.1987.tb11195.x

The antianaphylactic action of histamine H₂‐receptor agonists in the guinea‐pig isolated heart

P. Blandina, Sandra Brunelleschi, R. Fantozzi, Eliana Giannella, P. F. Mannaioni, Emanuela Masini

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The effects of histamine and of H₁‐and H₂‐receptor agonists on the response to specific antigen were studied in isolated hearts taken from actively sensitized guinea‐pigs. Histamine and H₂‐receptor agonists (dimaprit, impromidine) dose‐dependently decrease the positive chronotropic and inotropic effects, and the severity of arrhythmias evoked by the challenge of sensitized hearts with specific antigen. Nordimaprit and the selective H₁‐receptor agonist 2‐pyridyl‐ethyl‐amine (2‐PEA) did not modify the patterns of cardiac anaphylaxis. The positive inotropic and chronotropic responses of the isolated heart to exogenous histamine appear to be partly reduced in the presence of dimaprit. The H₂‐receptor agonists decrease the amount of histamine released during cardiac anaphylaxis which is increased by cimetidine, while nordimaprit and PEA were ineffective, indicating an inhibitory function afforded by H₂‐receptors in cardiac anaphylaxis. 1987 British Pharmacological Society

Lingua originale	Inglese
pagine (da-a)	459-466
Numero di pagine	8
Rivista	British Journal of Pharmacology
Volume	90
Numero di pubblicazione	3
DOI	https://doi.org/10.1111/j.1476-5381.1987.tb11195.x
Stato di pubblicazione	Pubblicato - mar 1987
Pubblicato esternamente	Sì

Accesso al documento

10.1111/j.1476-5381.1987.tb11195.x

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title = "The antianaphylactic action of histamine H2‐receptor agonists in the guinea‐pig isolated heart",

abstract = "The effects of histamine and of H1‐and H2‐receptor agonists on the response to specific antigen were studied in isolated hearts taken from actively sensitized guinea‐pigs. Histamine and H2‐receptor agonists (dimaprit, impromidine) dose‐dependently decrease the positive chronotropic and inotropic effects, and the severity of arrhythmias evoked by the challenge of sensitized hearts with specific antigen. Nordimaprit and the selective H1‐receptor agonist 2‐pyridyl‐ethyl‐amine (2‐PEA) did not modify the patterns of cardiac anaphylaxis. The positive inotropic and chronotropic responses of the isolated heart to exogenous histamine appear to be partly reduced in the presence of dimaprit. The H2‐receptor agonists decrease the amount of histamine released during cardiac anaphylaxis which is increased by cimetidine, while nordimaprit and PEA were ineffective, indicating an inhibitory function afforded by H2‐receptors in cardiac anaphylaxis. 1987 British Pharmacological Society",

author = "P. Blandina and Sandra Brunelleschi and R. Fantozzi and Eliana Giannella and Mannaioni, {P. F.} and Emanuela Masini",

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AU - Brunelleschi, Sandra

AU - Fantozzi, R.

AU - Giannella, Eliana

AU - Mannaioni, P. F.

AU - Masini, Emanuela

PY - 1987/3

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N2 - The effects of histamine and of H1‐and H2‐receptor agonists on the response to specific antigen were studied in isolated hearts taken from actively sensitized guinea‐pigs. Histamine and H2‐receptor agonists (dimaprit, impromidine) dose‐dependently decrease the positive chronotropic and inotropic effects, and the severity of arrhythmias evoked by the challenge of sensitized hearts with specific antigen. Nordimaprit and the selective H1‐receptor agonist 2‐pyridyl‐ethyl‐amine (2‐PEA) did not modify the patterns of cardiac anaphylaxis. The positive inotropic and chronotropic responses of the isolated heart to exogenous histamine appear to be partly reduced in the presence of dimaprit. The H2‐receptor agonists decrease the amount of histamine released during cardiac anaphylaxis which is increased by cimetidine, while nordimaprit and PEA were ineffective, indicating an inhibitory function afforded by H2‐receptors in cardiac anaphylaxis. 1987 British Pharmacological Society

AB - The effects of histamine and of H1‐and H2‐receptor agonists on the response to specific antigen were studied in isolated hearts taken from actively sensitized guinea‐pigs. Histamine and H2‐receptor agonists (dimaprit, impromidine) dose‐dependently decrease the positive chronotropic and inotropic effects, and the severity of arrhythmias evoked by the challenge of sensitized hearts with specific antigen. Nordimaprit and the selective H1‐receptor agonist 2‐pyridyl‐ethyl‐amine (2‐PEA) did not modify the patterns of cardiac anaphylaxis. The positive inotropic and chronotropic responses of the isolated heart to exogenous histamine appear to be partly reduced in the presence of dimaprit. The H2‐receptor agonists decrease the amount of histamine released during cardiac anaphylaxis which is increased by cimetidine, while nordimaprit and PEA were ineffective, indicating an inhibitory function afforded by H2‐receptors in cardiac anaphylaxis. 1987 British Pharmacological Society

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