TY - JOUR
T1 - The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study
AU - Sluijs, I
AU - NG, Forouhi
AU - JW, Beulens
AU - YT, van der Schouw
AU - Agnoli, C
AU - Arriola, L
AU - Balkau, B
AU - Barricarte, A
AU - Boeing, H
AU - HB, Bueno de Mesquita
AU - Clavel, Chapelon F
AU - FL, Crowe
AU - de Lauzon, Guillain B
AU - Drogan, D
AU - PW, Franks
AU - Gavrila, D
AU - Gonzalez, C
AU - Halkjaer, J
AU - Kaaks, R
AU - Moskal, A
AU - Nilsson, P
AU - Overvad, K
AU - Palli, D
AU - Panico, S
AU - JR, Quirós
AU - RICCERI, FULVIO
AU - Rinaldi, S
AU - Rolandsson, O
AU - SACERDOTE, Carlotta
AU - MJ, Sánchez
AU - Slimani, N
AU - AM, Spijkerman
AU - Teucher, B
AU - Tjonneland, A
AU - MJ, Tormo
AU - Tumino, R
AU - DL, van der A.
AU - SJ, Sharp
AU - Langenberg, C
AU - EJ, Feskens
AU - Riboli, E
AU - NJ, Wareham
AU - Consortium, InterAct
PY - 2012
Y1 - 2012
N2 - Background: Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products. Objective: The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these food groups. Design: A nested case-cohort within 8 European countries of the European Prospective Investigation into Cancer and Nutrition Study (n = 340,234; 3.99 million person-years of follow-up) included a random subcohort (n = 16,835) and incident diabetes cases (n = 12,403). Baseline dairy product intake was assessed by using dietary questionnaires. Country-specific Prentice-weighted Cox regression HRs were calculated and pooled by using a random-effects meta-analysis. Results: Intake of total dairy products was not associated with diabetes (HR for the comparison of the highest with the lowest quintile of total dairy products: 1.01; 95% CI: 0.83, 1.34; P-trend = 0.92) in an analysis adjusted for age, sex, BMI, diabetes risk factors, education, and dietary factors. Of the dairy subtypes, cheese intake tended to have an inverse association with diabetes (HR: 0.88; 95% CI: 0.76, 1.02; P-trend = 0.01), and a higher combined intake of fermented dairy products (cheese, yogurt, and thick fermented milk) was inversely associated with diabetes (HR: 0.88; 95% CI: 0.78, 0.99; P-trend = 0.02) in adjusted analyses that compared extreme quintiles. Conclusions: This large prospective study found no association between total dairy product intake and diabetes risk. An inverse association of cheese intake and combined fermented dairy product intake with diabetes is suggested, which merits further study.
AB - Background: Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products. Objective: The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these food groups. Design: A nested case-cohort within 8 European countries of the European Prospective Investigation into Cancer and Nutrition Study (n = 340,234; 3.99 million person-years of follow-up) included a random subcohort (n = 16,835) and incident diabetes cases (n = 12,403). Baseline dairy product intake was assessed by using dietary questionnaires. Country-specific Prentice-weighted Cox regression HRs were calculated and pooled by using a random-effects meta-analysis. Results: Intake of total dairy products was not associated with diabetes (HR for the comparison of the highest with the lowest quintile of total dairy products: 1.01; 95% CI: 0.83, 1.34; P-trend = 0.92) in an analysis adjusted for age, sex, BMI, diabetes risk factors, education, and dietary factors. Of the dairy subtypes, cheese intake tended to have an inverse association with diabetes (HR: 0.88; 95% CI: 0.76, 1.02; P-trend = 0.01), and a higher combined intake of fermented dairy products (cheese, yogurt, and thick fermented milk) was inversely associated with diabetes (HR: 0.88; 95% CI: 0.78, 0.99; P-trend = 0.02) in adjusted analyses that compared extreme quintiles. Conclusions: This large prospective study found no association between total dairy product intake and diabetes risk. An inverse association of cheese intake and combined fermented dairy product intake with diabetes is suggested, which merits further study.
UR - https://iris.uniupo.it/handle/11579/176736
U2 - 10.3945/ajcn.111.021907
DO - 10.3945/ajcn.111.021907
M3 - Article
SN - 0002-9165
VL - 96
SP - 382
EP - 390
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 2
ER -
