TY - JOUR
T1 - Terpenoids from Russula lepida and R. amarissima (Basidiomycota, Russulaceae)
AU - Clericuzio, Marco
AU - Cassino, Claudio
AU - Corana, Federica
AU - Vidari, Giovanni
N1 - Funding Information:
We would like to thank Maurizio Cossi ( Università del Piemonte Orientale, Italy ), for providing ab initio calculations, and MIUR (funds PRIN 2009) for partial funding support.
PY - 2012/12
Y1 - 2012/12
N2 - Four aristolane sesquiterpenes were isolated from the fruiting bodies of Russula lepida and R. amarissima, namely (1R,2S)-1,2-dihydroxyaristolone (6), (2S,11S)-2,12-dihydroxy-aristolone (7), (1R,2S,11S)-1,2,12-trihydroxyaristolone (8), (1S,2S,11S)-1,2,12-trihydroxy-aristolone (9). In addition, a seco-cucurbitane triterpene, i.e. 3,4-secocucurbita-4,24E-diene-3-hydroxy-26- carboxylic acid (14) was isolated from both species. The configuration at C-2 of the already known rulepidol (2-hydroxyaristolone, 5) was corrected as S instead of R. Several more aristolane and nardosinane sesquiterpenes, as well as cucurbitane triterpenes, already reported both from European and Chinese samples of R. lepida, were also isolated. Compound 14 showed moderate cell growth inhibitory activity.
AB - Four aristolane sesquiterpenes were isolated from the fruiting bodies of Russula lepida and R. amarissima, namely (1R,2S)-1,2-dihydroxyaristolone (6), (2S,11S)-2,12-dihydroxy-aristolone (7), (1R,2S,11S)-1,2,12-trihydroxyaristolone (8), (1S,2S,11S)-1,2,12-trihydroxy-aristolone (9). In addition, a seco-cucurbitane triterpene, i.e. 3,4-secocucurbita-4,24E-diene-3-hydroxy-26- carboxylic acid (14) was isolated from both species. The configuration at C-2 of the already known rulepidol (2-hydroxyaristolone, 5) was corrected as S instead of R. Several more aristolane and nardosinane sesquiterpenes, as well as cucurbitane triterpenes, already reported both from European and Chinese samples of R. lepida, were also isolated. Compound 14 showed moderate cell growth inhibitory activity.
KW - Aristolane
KW - Basidiomycota
KW - Cell growth inhibitory activity
KW - Cucurbitane
KW - Russula amarissima
KW - Russula lepida
KW - Sesquiterpenes
KW - Triterpenes
UR - http://www.scopus.com/inward/record.url?scp=84868147371&partnerID=8YFLogxK
U2 - 10.1016/j.phytochem.2012.07.024
DO - 10.1016/j.phytochem.2012.07.024
M3 - Article
SN - 0031-9422
VL - 84
SP - 154
EP - 159
JO - Phytochemistry
JF - Phytochemistry
ER -