TY - JOUR
T1 - TEAM Study
T2 - Upfront Docetaxel Treatment in Patients With Metastatic Hormone-Sensitive Prostate Cancer: A Real-World, Multicenter, Retrospective Analysis
AU - Pisano, Chiara
AU - Turco, Fabio
AU - Arnaudo, Elena
AU - Fea, Elena
AU - Vanella, Paola
AU - Ruatta, Fiorella
AU - Filippi, Roberto
AU - Brusa, Federica
AU - Prati, Veronica
AU - Vana, Federica
AU - Mennitto, Alessia
AU - Cattrini, Carlo
AU - Vignani, Francesca
AU - Dionisio, Rossana
AU - Icardi, Massimiliano
AU - Guglielmini, Pamela
AU - Buosi, Roberta
AU - Stevani, Ilaria
AU - Vormola, Roberto
AU - Numico, Gianmauro
AU - Depetris, Ilaria
AU - Comandone, Alessandro
AU - Gennari, Alessandra
AU - Airoldi, Mario
AU - Rossi, Maura
AU - Vellani, Giorgio
AU - Ortega, Cinzia
AU - Tucci, Marcello
AU - Maio, Massimo Di
AU - Buttigliero, Consuelo
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2024/4
Y1 - 2024/4
N2 - Background: Treatment of metastatic hormone-sensitive prostate cancer (mHSPC) dramatically changed. PEACE-1 and ARASENS trials established triplet therapy efficacy. Identifying prognostic factors supporting treatment choice is pivotal. Methods: TEAM is an observational, retrospective study to evaluate prognostic role of variables in mHSPC patients receiving upfront docetaxel in 11 Italian centers. Outcome measures were progression-free survival (PFS) and overall-survival (OS). Results: From September 2014 to December 2020, 147 patients were included. Median PFS and OS were 11.6 and 37.4 months. At univariate analysis, PFS-related variables were Gleason Score (GS) (P = .001), opioid use (P = .004), bone metastases number (P < .001), baseline PSA (P = .006), Hb (P < .001), ALP (P < .001) and LDH (P = .002), time between ADT and docetaxel start (P = .018), 3-month PSA (P < .001) and ALP (P < .001), and number of docetaxel cycles (P < .001). OS-related variables were PSA at diagnosis (P = .024), primary tumor treatment (P = .022), baseline pain (P = .015), opioid use (P < .001), bone metastases number (P < . 001), baseline Hb (P < .001), ALP (P < .001) and LDH (P = .001), NLR ratio (P = .039), 3-month PSA (P < .001) and ALP (P < .001) and docetaxel cycles number (P < .001). At multivariate analysis, independent prognostic variables were GS, opioid use, baseline LDH and time between ADT and docetaxel initiation for PFS, and baseline Hb and LDH for OS. Conclusion: Patients receiving upfront docetaxel with high GS, high disease burden, pain or opioid use, baseline unfavorable laboratory values had worse outcomes. Patients had greater docetaxel benefit when initiated early after ADT start. These parameters could be taken into account when selecting candidates for triplet therapy.
AB - Background: Treatment of metastatic hormone-sensitive prostate cancer (mHSPC) dramatically changed. PEACE-1 and ARASENS trials established triplet therapy efficacy. Identifying prognostic factors supporting treatment choice is pivotal. Methods: TEAM is an observational, retrospective study to evaluate prognostic role of variables in mHSPC patients receiving upfront docetaxel in 11 Italian centers. Outcome measures were progression-free survival (PFS) and overall-survival (OS). Results: From September 2014 to December 2020, 147 patients were included. Median PFS and OS were 11.6 and 37.4 months. At univariate analysis, PFS-related variables were Gleason Score (GS) (P = .001), opioid use (P = .004), bone metastases number (P < .001), baseline PSA (P = .006), Hb (P < .001), ALP (P < .001) and LDH (P = .002), time between ADT and docetaxel start (P = .018), 3-month PSA (P < .001) and ALP (P < .001), and number of docetaxel cycles (P < .001). OS-related variables were PSA at diagnosis (P = .024), primary tumor treatment (P = .022), baseline pain (P = .015), opioid use (P < .001), bone metastases number (P < . 001), baseline Hb (P < .001), ALP (P < .001) and LDH (P = .001), NLR ratio (P = .039), 3-month PSA (P < .001) and ALP (P < .001) and docetaxel cycles number (P < .001). At multivariate analysis, independent prognostic variables were GS, opioid use, baseline LDH and time between ADT and docetaxel initiation for PFS, and baseline Hb and LDH for OS. Conclusion: Patients receiving upfront docetaxel with high GS, high disease burden, pain or opioid use, baseline unfavorable laboratory values had worse outcomes. Patients had greater docetaxel benefit when initiated early after ADT start. These parameters could be taken into account when selecting candidates for triplet therapy.
KW - Docetaxel
KW - Metastatic hormone-sensitive prostate cancer
KW - Prognostic factors
KW - Triplet therapy
UR - http://www.scopus.com/inward/record.url?scp=85173159275&partnerID=8YFLogxK
U2 - 10.1016/j.clgc.2023.08.006
DO - 10.1016/j.clgc.2023.08.006
M3 - Article
SN - 1558-7673
VL - 22
SP - 56-67.e16
JO - Clinical Genitourinary Cancer
JF - Clinical Genitourinary Cancer
IS - 2
ER -
