Synthesis of selectively permodified γ-cyclodextrins. A new set of chiral stationary phases in capillary GC

Two pairs of new chiral selectors, derived from octakis(6-O-t-butyldimethylsilyl)-and octakis(6-O-t-hexyldimethylsilyl)-γ-cyclodextrin, were synthesized with inverse substitution patterns at the secondary positions. 2-O-methyl-3-O-acetyl-and 2-O-acetyl-3-O-methyl derivatives are suggested as useful models to further investigate the effect of substituents at C-2 and C-3 on the efficiency of enantio-separation using gas chromatography.