Abstract
The azide-functionalized PtIV complex {(OC-6-34)-chlorido(cyclobutane-1,1′-dicarboxylato)(cyclohexane-1R,2R-diamine)[2-hydroxyethyl(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl)carbamate]platinum(IV)} was synthesized and characterized to obtain a starting complex that was suitable for coupling with appropriate biological carriers in a drug targeting and delivery strategy. The following click reaction (CuI-catalyzed Huisgen cycloaddition, CuAAC) was successfully applied for coupling with three different model biomolecules that can be exploited for selective targeting of the platinum conjugate toward tumor cells; i.e., the amino acid alanine and the dipeptide lysine-alanine, both previously alkyne-functionalized with pent-4-ynoic acid, and the hormone 17α-ethynylestradiol. The title complex demonstrated very good compatibility with both CuAAC reaction and solid-phase peptide synthesis conditions, making it a suitable antiproliferative fragment for the design of nanovectors.
Lingua originale | Inglese |
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pagine (da-a) | 5335-5341 |
Numero di pagine | 7 |
Rivista | European Journal of Inorganic Chemistry |
Volume | 2015 |
Numero di pubblicazione | 32 |
DOI | |
Stato di pubblicazione | Pubblicato - 1 nov 2015 |