Synthesis of paclitaxel (docetaxel) / 2-deacetoxytaxinine J dimers

Giovanni Appendino; Emanuela Belloro; Sven Jakupovic; Bruno Danieli; Jasmin Jakupovic; Ezio Bombardelli

doi:10.1016/S0040-4020(99)00290-2

Synthesis of paclitaxel (docetaxel) / 2-deacetoxytaxinine J dimers

Giovanni Appendino, Emanuela Belloro, Sven Jakupovic, Bruno Danieli, Jasmin Jakupovic, Ezio Bombardelli

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Starting from taxanes available in multigram amounts from widespread ornamental yews (10-deacetylbaccatin III (4) and 2'-deacetoxyaustrospicatine (5)), two dimeric taxoids (3a, 3b) with potential dual target specificity (β-tubulin and P-gp) were synthesised. Both compounds lacked significant cytotoxicity, though 3b retained a strong activity in the tubulin depolimerisation assay.

Lingua originale	Inglese
pagine (da-a)	6567-6576
Numero di pagine	10
Rivista	Tetrahedron
Volume	55
Numero di pubblicazione	21
DOI	https://doi.org/10.1016/S0040-4020(99)00290-2
Stato di pubblicazione	Pubblicato - 21 mag 1999
Pubblicato esternamente	Sì

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10.1016/S0040-4020(99)00290-2

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title = "Synthesis of paclitaxel (docetaxel) / 2-deacetoxytaxinine J dimers",

abstract = "Starting from taxanes available in multigram amounts from widespread ornamental yews (10-deacetylbaccatin III (4) and 2'-deacetoxyaustrospicatine (5)), two dimeric taxoids (3a, 3b) with potential dual target specificity (β-tubulin and P-gp) were synthesised. Both compounds lacked significant cytotoxicity, though 3b retained a strong activity in the tubulin depolimerisation assay.",

keywords = "Antitumour compounds, Dimers, Taxoids",

author = "Giovanni Appendino and Emanuela Belloro and Sven Jakupovic and Bruno Danieli and Jasmin Jakupovic and Ezio Bombardelli",

year = "1999",

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doi = "10.1016/S0040-4020(99)00290-2",

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T1 - Synthesis of paclitaxel (docetaxel) / 2-deacetoxytaxinine J dimers

AU - Appendino, Giovanni

AU - Belloro, Emanuela

AU - Jakupovic, Sven

AU - Danieli, Bruno

AU - Jakupovic, Jasmin

AU - Bombardelli, Ezio

PY - 1999/5/21

Y1 - 1999/5/21

N2 - Starting from taxanes available in multigram amounts from widespread ornamental yews (10-deacetylbaccatin III (4) and 2'-deacetoxyaustrospicatine (5)), two dimeric taxoids (3a, 3b) with potential dual target specificity (β-tubulin and P-gp) were synthesised. Both compounds lacked significant cytotoxicity, though 3b retained a strong activity in the tubulin depolimerisation assay.

AB - Starting from taxanes available in multigram amounts from widespread ornamental yews (10-deacetylbaccatin III (4) and 2'-deacetoxyaustrospicatine (5)), two dimeric taxoids (3a, 3b) with potential dual target specificity (β-tubulin and P-gp) were synthesised. Both compounds lacked significant cytotoxicity, though 3b retained a strong activity in the tubulin depolimerisation assay.

KW - Antitumour compounds

KW - Dimers

KW - Taxoids

UR - https://www.scopus.com/pages/publications/0033591156

U2 - 10.1016/S0040-4020(99)00290-2

DO - 10.1016/S0040-4020(99)00290-2

M3 - Article

SN - 0040-4020

VL - 55

SP - 6567

EP - 6576

JO - Tetrahedron

JF - Tetrahedron

IS - 21

ER -

Synthesis of paclitaxel (docetaxel) / 2-deacetoxytaxinine J dimers

Abstract

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