Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption

Loretta Lazzarato, Barbara Rolando, Marco L. Lolli, Gian Cesare Tron, Roberta Fruttero, Alberto Gasco, Guido Deleide, Harald L. Guenther

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

A new class of bisphosphonates containing nitrooxy NO-donor functions has been developed. The products proved to display affinity for hydroxyapatite. Injection of 99mTc-labeled derivatives 11 and 18 into male rats showed a preferential accumulation of the compounds in bone as compared to blood and muscles. The products were found to inhibit the differentiation of preosteoclasts to functional osteoclasts induced by receptor activator of NF-κB ligand (RANKL), through a prevalent NO-dependent mechanism.

Lingua originaleInglese
pagine (da-a)1322-1329
Numero di pagine8
RivistaJournal of Medicinal Chemistry
Volume48
Numero di pubblicazione5
DOI
Stato di pubblicazionePubblicato - 10 mar 2005

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