Synthesis of Heteroarylogous 1H-Indole-3-Carboxamidines Through a Three-Component Interrupted Ugi Reaction

Fabio La Spisa; Fiorella Meneghetti; Beatrice Pozzi; Gian Cesare TRON

doi:10.1055/s-0034-1378921

Synthesis of Heteroarylogous 1H-Indole-3-Carboxamidines Through a Three-Component Interrupted Ugi Reaction

Fabio La Spisa, Fiorella Meneghetti, Beatrice Pozzi, Gian Cesare TRON

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A novel one-pot multicomponent synthesis of heteroarylogous 1H-indole-3-carboxamidines starting from readily available N-alkyl-N-(1H-indol-2-ylmethyl)amines, isocyanides, and carbonyl compounds is reported. The strategy exploits the ability of the indole nucleus to interrupt the classical Ugi reaction, by intercepting the nascent nitrilium ion.

Lingua originale	Inglese
pagine (da-a)	489-496
Numero di pagine	8
Rivista	Synthesis
Volume	47
DOI	https://doi.org/10.1055/s-0034-1378921
Stato di pubblicazione	Pubblicato - 2015

Accesso al documento

10.1055/s-0034-1378921

http://hdl.handle.net/11579/69977

Altri file e collegamenti

handle

Cita questo

@article{5def90e02c0e4a74ad09f6ee43082b83,

title = "Synthesis of Heteroarylogous 1H-Indole-3-Carboxamidines Through a Three-Component Interrupted Ugi Reaction",

abstract = "A novel one-pot multicomponent synthesis of heteroarylogous 1H-indole-3-carboxamidines starting from readily available N-alkyl-N-(1H-indol-2-ylmethyl)amines, isocyanides, and carbonyl compounds is reported. The strategy exploits the ability of the indole nucleus to interrupt the classical Ugi reaction, by intercepting the nascent nitrilium ion.",

author = "\{La Spisa\}, Fabio and Fiorella Meneghetti and Beatrice Pozzi and TRON, \{Gian Cesare\}",

note = "Publisher Copyright: {\textcopyright} Georg Thieme Verlag Stuttgart · New York.",

year = "2015",

doi = "10.1055/s-0034-1378921",

language = "English",

volume = "47",

pages = "489--496",

journal = "Synthesis",

issn = "0039-7881",

publisher = "Georg Thieme Verlag",

}

TY - JOUR

T1 - Synthesis of Heteroarylogous 1H-Indole-3-Carboxamidines Through a Three-Component Interrupted Ugi Reaction

AU - La Spisa, Fabio

AU - Meneghetti, Fiorella

AU - Pozzi, Beatrice

AU - TRON, Gian Cesare

PY - 2015

Y1 - 2015

N2 - A novel one-pot multicomponent synthesis of heteroarylogous 1H-indole-3-carboxamidines starting from readily available N-alkyl-N-(1H-indol-2-ylmethyl)amines, isocyanides, and carbonyl compounds is reported. The strategy exploits the ability of the indole nucleus to interrupt the classical Ugi reaction, by intercepting the nascent nitrilium ion.

AB - A novel one-pot multicomponent synthesis of heteroarylogous 1H-indole-3-carboxamidines starting from readily available N-alkyl-N-(1H-indol-2-ylmethyl)amines, isocyanides, and carbonyl compounds is reported. The strategy exploits the ability of the indole nucleus to interrupt the classical Ugi reaction, by intercepting the nascent nitrilium ion.

UR - https://iris.uniupo.it/handle/11579/69977

U2 - 10.1055/s-0034-1378921

DO - 10.1055/s-0034-1378921

M3 - Article

SN - 0039-7881

VL - 47

SP - 489

EP - 496

JO - Synthesis

JF - Synthesis

ER -

Synthesis of Heteroarylogous 1H-Indole-3-Carboxamidines Through a Three-Component Interrupted Ugi Reaction

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo