Synthesis of disaccharidic sub-units of a new series of heparin related oligosaccharides

Barbara La Ferla; Luigi Lay; Marco Guerrini; Laura Poletti; Luigi Panza; Giovanni Russo

doi:10.1016/S0040-4020(99)00526-8

Synthesis of disaccharidic sub-units of a new series of heparin related oligosaccharides

Barbara La Ferla, Luigi Lay, Marco Guerrini, Laura Poletti, Luigi Panza, Giovanni Russo

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The chemical synthesis of disaccharides 1 and 2, useful building-blocks for the preparation of a new series of heparin related oligosaccharides containing the unusual sequence (GlcN-IdoA)(n), is described. In addition, the orthogonality of the protective groups would allow access to a wide array of differently sulfated oligosaccharides. As the simplest members of this new class of oligomer, the synthesis of sulfated disaccharides 3 and 4 fully deprotected is reported.

Lingua originale	Inglese
pagine (da-a)	9867-9880
Numero di pagine	14
Rivista	Tetrahedron
Volume	55
Numero di pubblicazione	32
DOI	https://doi.org/10.1016/S0040-4020(99)00526-8
Stato di pubblicazione	Pubblicato - 6 ago 1999
Pubblicato esternamente	Sì

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10.1016/S0040-4020(99)00526-8

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title = "Synthesis of disaccharidic sub-units of a new series of heparin related oligosaccharides",

abstract = "The chemical synthesis of disaccharides 1 and 2, useful building-blocks for the preparation of a new series of heparin related oligosaccharides containing the unusual sequence (GlcN-IdoA)(n), is described. In addition, the orthogonality of the protective groups would allow access to a wide array of differently sulfated oligosaccharides. As the simplest members of this new class of oligomer, the synthesis of sulfated disaccharides 3 and 4 fully deprotected is reported.",

keywords = "Biologically active compounds, Carbohydrates, Glycosidation, Sulfonation",

author = "{La Ferla}, Barbara and Luigi Lay and Marco Guerrini and Laura Poletti and Luigi Panza and Giovanni Russo",

note = "Funding Information: Acknowled~,ements - We thank ELI (CARENET-2 project, contract ERB-FMRX-CT 96-0025) and MURST (Ministero dell'Universita e della Ricerca Scientifica e Tecnologica) for financial support.",

year = "1999",

month = aug,

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doi = "10.1016/S0040-4020(99)00526-8",

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T1 - Synthesis of disaccharidic sub-units of a new series of heparin related oligosaccharides

AU - La Ferla, Barbara

AU - Lay, Luigi

AU - Guerrini, Marco

AU - Poletti, Laura

AU - Panza, Luigi

AU - Russo, Giovanni

N1 - Funding Information: Acknowled~,ements - We thank ELI (CARENET-2 project, contract ERB-FMRX-CT 96-0025) and MURST (Ministero dell'Universita e della Ricerca Scientifica e Tecnologica) for financial support.

PY - 1999/8/6

Y1 - 1999/8/6

N2 - The chemical synthesis of disaccharides 1 and 2, useful building-blocks for the preparation of a new series of heparin related oligosaccharides containing the unusual sequence (GlcN-IdoA)(n), is described. In addition, the orthogonality of the protective groups would allow access to a wide array of differently sulfated oligosaccharides. As the simplest members of this new class of oligomer, the synthesis of sulfated disaccharides 3 and 4 fully deprotected is reported.

AB - The chemical synthesis of disaccharides 1 and 2, useful building-blocks for the preparation of a new series of heparin related oligosaccharides containing the unusual sequence (GlcN-IdoA)(n), is described. In addition, the orthogonality of the protective groups would allow access to a wide array of differently sulfated oligosaccharides. As the simplest members of this new class of oligomer, the synthesis of sulfated disaccharides 3 and 4 fully deprotected is reported.

KW - Biologically active compounds

KW - Carbohydrates

KW - Glycosidation

KW - Sulfonation

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U2 - 10.1016/S0040-4020(99)00526-8

DO - 10.1016/S0040-4020(99)00526-8

M3 - Article

SN - 0040-4020

VL - 55

SP - 9867

EP - 9880

JO - Tetrahedron

JF - Tetrahedron

IS - 32

ER -

Synthesis of disaccharidic sub-units of a new series of heparin related oligosaccharides

Abstract

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