Synthesis of bifunctional chelating agents based on mono and diphosphonic derivatives of diethylenetriaminepentaacetic acid

Giovanni B. Giovenzana, Claudia Guanci, Silvia Demattio, Luciano Lattuada, Veronica Vincenzi

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Bifunctional chelating agents (BFCAs) are small molecules containing a chelating unit, able to strongly coordinate a metal ion, and a reactive functional group, devised to form a stable covalent bond with another molecule. BFCAs are widely employed since their conjugation to a suitable biomolecule (e.g., a peptide or an antibody) allows the synthesis of diagnostic or therapeutic agents that specifically target diseased tissue with metals or radiometals. For this reason, BFCAs find application in diagnostic imaging, molecular imaging, and radiotherapy of cancer. The synthesis of new BFCAs based on a diethylenetriaminepentaacetic acid (DTPA) structure in which one or two carboxylic groups are replaced with phosphonic units is described. The phosphonic group, aside from being a classical isostere of the carboxylic acid in coordination chemistry, allows to modulate the physico-chemical properties of the ligands and of the corresponding complexes.

Lingua originaleInglese
pagine (da-a)4809-4813
Numero di pagine5
RivistaTetrahedron
Volume70
Numero di pubblicazione32
DOI
Stato di pubblicazionePubblicato - 12 ago 2014

Fingerprint

Entra nei temi di ricerca di 'Synthesis of bifunctional chelating agents based on mono and diphosphonic derivatives of diethylenetriaminepentaacetic acid'. Insieme formano una fingerprint unica.

Cita questo